【摘要】 目的探讨营养支持治疗联合壮药复方合剂辅助治疗对艾滋病患者抗病毒治疗临床疗效的影响。方法收集自2015年1月至2015年10月在贵港市人民医院艾滋病门诊就诊未抗病毒治疗且合并营养不良的艾滋病患者80例,随机分为4组,每组各20例。分别给予抗病毒治疗(抗病毒组)、抗病毒治疗基础上加营养素治疗(营养辅助组),抗病毒治疗基础上加壮药治疗(壮药辅助组),抗病毒治疗联合营养素及壮药治疗(联合组),干预6个月。检测治疗前后患者肝肾功能、血常规,使用流式细胞仪检测治疗前后免疫细胞CD4~+、CD8~+淋巴细胞计数。结果治疗前各组研究对象血清白蛋白(SB)、谷丙转氨酶、肌酐、血红蛋白水平比较,差异无统计学意义(P>0.05)。治疗后营养辅助组、壮药辅助组、联合组血清白蛋白、血红蛋白水平较抗病毒组高,联合组SB、血红蛋白水平较营养辅助组及壮药辅助组高,壮药辅助组及联合组转氨酶水平较抗病毒组、营养辅助组低,联合组肌酐水平较抗病毒组、营养辅助组低,差异有统计学意义(P<0.05)。治疗前各组CD4~+、CD8~+T淋巴细胞水平差异无统计学意义(P>0.05)。治疗后抗病毒组、营养辅助组、壮药辅助组、联合组CD4~+T淋巴细胞水平分别为(259.8±123.81)、(376.3±110.43)、(393.9±136.08)、(487.9±117.64)/μL,CD8~+T淋巴细胞水平分别为(715.1±174.73)、(654.7±185.50)、(669.9±207.89)、(689.1±156.03)/μL。治疗后各组CD4~+T淋巴细胞水平差异有统计学意义(F=11.714,P<0.05),其中营养辅助组、壮药辅助组、联合组CD4~+T淋巴细胞水平较抗病毒组高,联合组CD4~+T淋巴细胞水平较营养辅助组、壮药辅助组高,差异均有统计学意义(P<0.05)。治疗后各组CD8~+T淋巴细胞水平差异无统计学意义(P>0.05)。结论营养支持及壮药辅助治疗有利于改善抗病毒治疗的艾滋病患者营养状况及促进免疫重建,对艾滋病的治疗具有协同作用。更多还原

【Abstract】 Objective This study aimed to investigate the clinical curative effect of nutritional support therapy combine with Zhuang medicine compound mixture in AIDS patients with antiviral therapy. Methods 80 AIDS patients who were suffered from malnutrition and non-antiviral treatment from the People′s Hospital of Guigang city were include in this study.They were randomly divided into four groups. The fist group was treated with Highly Active Anti-retroviral therapy(the antiviral group).On the basis of antiviral therapy,the second group was added with nutritionalsupport(the nutritional support group);the third group was added with Zhuang medicine compound mixture(the Zhuang medicine group),and the fourth group was added with nutritional support and Zhuang medicine therapy(the combined treatment group). All patients were followed up for 6 months. The serum levels of CD4~+ and CD8~+ T lymphocytes,liver function,renal function,blood routine examination were measured before and afer treatment. Results The serum albumin,glutamic-pyruvictransaminase,creatinine,hemoglobin levels among four groups pretherapy had no significant differences. After 6 months of treatment,the serum albumin,hemoglobin levels of the nutritionalsupport group,the Zhuang medicine group and the combined treatment group were higher than the antiviral group;the difference was statistically significant. CD4~+ and CD8~+ T lymphocytes levels among four groups pretherapy had no significant differences(P>0.05). After 6 months of treatment,CD4~+ T lymphocytes levels of the antiviral group,the nutritional support group,the Zhuang medicine group and the combined treatment group were(715.1±174.73),(654.7±185.50),(669.9±207.89)and(689.1±156.03)/μL,respectively,and the CD8~+ T lymphocytes levels were(259.8±123.81),(376.3±110.43),(393.9±136.08)and(487.9±117.64)/μL,respectively. There were significant differences of the CD4~+ T lymphocytes levels among four groups(F=11.714,P<0.05). The CD4~+ T lymphocytes levels of the nutritional support group,the Zhuang medicine group and the combined treatment group were higher than that of the antiviral group. The CD4~+ T lymphocytes levels of the combined treatment group were higher than that of the nutritional support group and the Zhuang medicine group. There was no significant difference of the CD8~+ T lymphocytes levels among four groups post-treatment(P>0.05).Conclusions Nutritional support and the Zhuang medicine auxiliary treatment was beneficial to improve the nutrition status of AIDS patients and promote immune reconstruction,and had cooperativeeffect on the treatment of AIDS who were under the antiviral therapy.更多还原