【摘要】 目的探讨HBsAg(+)/核酸检测(nucleic acid test,NAT)(-)献血者的乙肝表面抗原(hepatitis B surface antigen,HBsAg)定量水平和血清学特征。方法对104名HBsAg(+)/NAT(-)献血者进行HBsAg定量检测和HBV两对半检测,对HBsAg定量结果进行统计学描述,比较不同HBV血清学模式组的HBsAg定量。结果广州地区HBsAg(+)/NAT(-)献血者在无偿献血者中的占比为0.19%,在HBsAg双试剂确认阳性献血者中的占比为24.87%;HBsAg定量均处于中低水平并以低水平(HBsAg<100 IU/m L)为主(97.12%,101/104),中位数为1.16 IU/m L;两对半检测均为HBeAg阴性,共出现8种血清学组合模式,以小三阳"145"模式最多(56.73%,59/104);HBsAb阳性者较单HBeAb阳性者的HBsAg定量低,差异具有统计学意义(P<0.05)。结论获得HBsAg(+)/NAT(-)献血者的HBsAg定量水平和血清学特征,为评价其血液安全性提供了一定的实验依据。更多还原

【Abstract】 Objective To investigate HBsAg titer and serological characteristics of HBsAg(+)/nucleic acid test(NAT)(-)blood donors.MethodsBlood samples of 104 HBsAg(+)/NAT(-)blood donors of Guangzhou were tested for quantified HBsAg and five serological markers of HBV,statistically.HBsAg titer was described and compared among different serological HBV patterns.Results The detection rate of HBsAg(+)/NAT(-)was 0.19%among all blood donors and was 24.87%among blood donors who were HBsAg(+).The median titer of HBsAg was 1.16 IU/ml and median-low titer(HBsAg<100 IU/m L)were predominant(97.12%,101/104).Determining of serum marks of HBV were HBe Ag negative.There were 8 different models found in this study,of which the models"145"was predominant(56.73%,59/104).There was significant difference in quantified HBsAg between the group of HBs Ab(+)and of HBe Ab(+)(P<0.05).ConclusionThe findings of HBsAg titer and serological characteristics of HBsAg(+)/NAT(-)blood donors provided evidence to evaluate the safety of blood from them.更多还原