【摘要】 目的探讨PPARγ激活对糖尿病兔骨折愈合的影响。方法选取浙江中医药大学动物实验研究中心2016年6月普通级健康雄性兔18只,随机分成对照组、糖尿病组和PPARγ激活组,各6只。糖尿病组和PPARγ激活组建立高血糖动物模型,3组均建立骨折模型。比较3组空腹血糖（FPG）、三酰甘油（TG）、骨形态发生蛋白2（BMP-2）、转化生长因子β₁（TGF-β₁）、血小板衍生因子（PDGF）、碱性成纤维细胞生长因子（bFGF）水平及体质量。结果给药前,3组兔体质量比较,差异无统计学意义（P>0.05）;糖尿病组与PPARγ激活组FPG、TG水平高于对照组（P<0.05）,而糖尿病组与PPARγ激活组FPG、TG水平比较,差异无统计学意义（P>0.05）。给药后,糖尿病组、PPARγ激活组体质量低于对照组,FPG、TG水平高于对照组（P<0.05）;PPARγ激活组体质量高于糖尿病组,FPG、TG水平低于糖尿病组（P<0.05）。糖尿病组治疗1、2、3周时BMP-2、TGF-β₁、bFGF水平低于对照组,治疗1周时PDGF水平低于对照组（P<0.05）;PPARγ激活组治疗1、2、3周时bFGF水平低于糖尿病组,治疗2、3周时BMP-2、TGF-β₁、PDGF水平低于糖尿病组（P<0.05）。结论 PPARγ激活后可造成糖尿病患者骨质流失,不利于骨折的愈合。更多还原

【Abstract】 Objective To discuss the impact of PPARγ activation on fracture healing of diabetes mellitus rabbit.Methods A total of 18 cases of regular grade healthy male rabbits were selected in Zhejiang University of Traditional Chinese Medicine Animal Experimental Research Centerin in June 2016, which were divided into control group, diabetes group and PPARγ activated group,6 cases in each group. Diabetes group and PPARγ activated group were established animal model of hyperglycemia,all groups were established animal model of fracture. The FPG,TG,BMP-2,TGF-β₁,PDGF,bFGF levels and body mass were compared among three groups. Results Before treatment,no significant difference in body mass was found among three groups（ P > 0. 05）; the FPG,TG levels of diabetes group and PPARγ activated group were higher than control group（ P < 0. 05）,no significant differences in FPG,TG levels was found between the diabetes group and PPARγ activated group（ P > 0. 05）. After treatment,the diabetes group and PPARγ activated group of body mass were lower than control group,FPG、TG levels were higher than control group（ P < 0. 05）; the PPARγ activated group of body mass were lower than diabetes group,FPG、TG levels were higher than diabetes group（ P < 0. 05）. The diabetes group of BMP-2,TGF-β₁,bFGF levels were lower than control group after treatment of 1,2,3 weeks,PDGF level was lower than control group after treatment of 1week（ P < 0. 05）; the PPARγ activated group of bFGF level was lower than diabetes group after treatment of 1,2,3 weeks,BMP-2,TGF-β₁,PDGF levels were lower than diabetes group after treatment of 2,3 weeks（ P < 0. 05）. Conclusion PPARγ activation can cause bone loss of diabetic patients,it’s not good for fracture healing.更多还原