Objective To discuss the clinical significance of MMP-9 value in early diagnosis of severe acute pancreatitis.Methods The health people,non-pancreatitis with acute abdominal pain patients,mild acute pancreatitis patients and severe acute pancreatitis were collected and divided into four groups. The serum admitted within 24 hours in hospital were collected. MMP-9 in the serum were measured and analyzed by variance analysis and ROC curve graph. Results The serum level of MMP-9 in the pancreatitis patients was...