【摘要】 目的:研究非小细胞肺癌组织表皮生长因子受体（EGFR）突变情况与肿瘤组织¹⁸F-脱氧葡萄糖(¹⁸F-FDG)摄取的关系。方法:回顾性分析经病理证实的126例非小细胞肺癌患者的临床资料,于治疗前行¹⁸F-FDG PET/CT检查及EGFR基因突变检测,分析FDG最大标准摄取值(SUV_max)与EGFR突变之间的关系。结果:本组病例中有51例患者（40.5%）19及21外显子突变,突变型患者原发灶的SUV_max低于野生型患者（6±4 vs 11±6,P=0.014）,用SUV_max预测EGFR突变时,受试者工作特征曲线（ROC曲线）下面积是0.769,P=0.001;当SUV_max取界值8.15时,约登指数最大为0.455。结论:非小细胞肺癌原发灶¹⁸F-FDG摄取与EGFR突变存在相关性,EGFR突变更易发生在低SUV_max患者。更多还原

【Abstract】 Objective: To evaluate the relationship between the presence of epidermal growth factor receptor（EGFR） mutations and 18-fluoro-2-deoxyglucose(¹⁸F-FDG) uptake of primary tumor in patients with non-small cell lung cancer（NSCLC）.Methods: Totally 126 patients with NSCLC diagnosed by pathology were collected,who underwent PET/CT examinations and EGFR mutation tests before any anti-tumor therapies,the relationship between the maximum standard uptake value(SUV_max) and the EGFR mutation was analyzed.Results: EGFR mutations within exons 19 and 21 were detected in 51 NSCLC patients（40.5%）,the SUV_maxwas significantly lower in EGFR mutant-type than wild-type（6 ± 4 vs 11 ± 6,P = 0.014）.For the prediction of EGFR mutations by SUV_max,the area under the receiver operating characteristic curve（AUC） was 0.769,P = 0.001.When the cut off value was8.15,the Youden index reached the maximum value 0.455.Conclusion:¹⁸F-FDG uptake is associated with the presence of EGFR mutation,patients with lower SUV_maxare more likely to harbor EGFR mutations.更多还原