【摘要】 目的探讨肾透明细胞癌(RCC)中是否存在血管生成拟态(VM)以及是否表达血管上皮钙粘附素(VE-cadherin),并进一步阐述VM与VE-cadherin的临床意义及二者与患者临床预后之间的关系。方法收集44例临床及随访资料完整的RCC患者的病例,进行过碘酸雪夫氏染色(PAS)与CD31双重染色以及VE-cadherin免疫组织化学染色法检测RCC组织中是否存在VM以及VE-cadherin的表达。结果 79.6%(35/44)的RCC患者存在VM,且VM与病理分级、临床分期显著相关(P<0.05),与患者年龄、性别、肾包膜浸润、转移及预后无关。RCC中VE-cadherin阳性率为65.9%(29/44),其表达与年龄、性别、临床分期、肾包膜浸润、预后无关,但与病理分级显著相关(P<0.05)。结论 RCC中存在VM以及VE-cadherin的表达,初步研究认为RCC的恶性度越高VM形成能力越强,VE-cadherin的表达也越高,VM与VE-cadherin之间存在正相关关系,推测他们与肾癌的恶性生物学行为有关。更多还原

【Abstract】 Objectives To explore whether vasculogenic mimicry(VM)and vascular epithelium cadherin(VE-cadherin)exist in renal clear cell carcinoma(RCC),and to explain the clinical significance of VM and VE-cadherin and their relationship with the prognosis of RCC.Methods A total of 44 RCC tissue specimens with complete clinical and prognostic data were retrospectively reviewed.The presence of VM in RCC was examined by periodic acid-schiff(PAS)staining with CD31 double staining technique,and the expression of VE-cadherin was detected by immunohistochemical staining.Results VM was detected in 79.6%(35/44)of RCC specimens.VM was significantly correlated to pathological grade and clinical staging(P<0.05),but not to age,sex,renal capsule invasion,metastasis and prognosis.The positive rate of VE-cadherin was 65.9%(29/44).Its expression was not related to age,sex,clinical stage,renal capsule infiltration and prognosis,but significantly to pathological grade(P<0.05).Conclusions VM and VE-cadherin exist in RCC.The more invasive RCCs exhibit more VM and VE-cadherin expressions than the less vicious RCCs.VM is positively related to the expression of VE-cadherin,and they may contribute to the invasiveness of RCC.更多还原