【摘要】 目的研究脂蛋白磷脂酶A2活性与动脉粥样硬化斑块稳定性的相关性,探讨脂蛋白磷脂酶A2活性是否是易损斑块的危险因子。方法根据颈动脉彩超或冠脉造影检出斑块,冠脉造影检出冠脉闭塞,将研究对象分为4组:无斑块组、稳定斑块组、不稳定斑块组和破裂斑块组,分别检测并对比分析四组脂蛋白磷脂酶A2活性(Lp-PLA2)、超敏C反应蛋白(hsCRP)、低密度脂蛋白(LDLC)、五聚素3(PTX3)等。结果四组间Lp-PLA2、LDLC、hs-CRP、PTX3水平间差异具有统计学意义(P<0.05),稳定斑块组、不稳定斑块组和破裂斑块组的Lp-PLA2、LDLC、hs-CRP、PTX3水平均显著高于无斑块组,不稳定斑块组和破裂斑块组的Lp-PLA2、LDLC、PTX3水平均显著高于稳定斑块组,破裂斑块组的Lp-PLA2、LDLC、hs-CRP、PTX3水平均显著高于不稳定斑块组;Logistic回归分析最后筛选出Lp-PLA2、LDLC、hs-CRP、PTX3为斑块稳定的影响因素(P<0.05),且均为危险因素。结论脂蛋白磷脂酶A2活性与动脉粥样硬化斑块稳定性紧密相关,且为危险因素,对斑块稳定存在一定程度的预测作用。更多还原

【Abstract】 Objective To study the relationship between lipoprotein phospholipase A2 activity and the stability of atherosclerotic plaques,and to explore whether lipoprotein phosphatase A2 activity is a risk factor for vulnerable plaques. Methods The coronary arteries were detected by carotid ultrasonography or coronary angiography. Coronary occlusion was performed. The subjects were divided into four groups: no plaque group,stable plaque group,unstable plaque group and ruptured plaque(Lp-PLA2),hypersensitive C-reactive protein(hs-CRP),low density lipoprotein(LDLC) and pentosan 3(PTX3) were detected and compared. Results The differences of Lp-PLA2,LDLC,hs-CRP and PTX3 between the four groups were statistically significant(P < 0. 05),Lp-PLA2,LDLC,Lp-PLA2,LDL,Hs-CRP and PTX3 were significantly higher than those in the non-plaque group,and the levels of Lp-PLA2,LDLC and PTX3 in the unstable plaque group and the ruptured plaque group were significantly higher than those in the stable plaque group,(P < 0. 05). The expression of Lp-PLA2,LDLC,hs-CRP and PTX3 were significantly higher than those of the untreated plaque group(P < 0. 05). Logistic regression analysis showed that Lp-PLA2,LDLC,hs-And are risk factors. Conclusion The activity of lipoprotein phospholipase A2 is closely related to the stability of atherosclerotic plaque,and it is a risk factor,which has a certain degree of predictive effect on plaque stability.更多还原