【摘要】 目的分析发泡试验阳性的隐源性卒中(CS)患者的临床特点。方法收集急性缺血性卒中患者350例;TOAST分型,118例确定为CS;对此组患者进行TCD发泡试验检查,并详细记录临床、生化与神经影像学等资料。结果 118例患者TCD发泡试验阳性46例(39.0%);阳性患者平均年龄为54.28±8.56岁,男性36例(78.3%),女性10例(21.7%);高血压病的发生率为65.2%。临床上表现为脑梗死39例/46例(占84.8%)、TIA7例/46例(占15.2%);前循环脑梗死33例/46例(占84.6%),后循环脑梗死6例/46例(占15.4%);多发病灶34例/46例(占87.2%),单发病灶5例/46例(占12.8%);NIHSS评分0~3分27例/46例(占69.2%),4~10分8例/46例(占20.5%),11分以上4例/46例(占10.3%);微泡分级Ⅰ~Ⅱ级39例/46例(占84.8%),Ⅲ~Ⅳ级7例/46例(占15.2%)。结论 TCD发泡试验阳性的CS患者的临床特点是多发于中青年男性患者,以前循环多发脑梗死为主,神经功能缺损相对较轻,65.2%合并高血压。更多还原

【Abstract】 Objective To investigate clinical characteristics of cryptogenic stroke(CS) in the patients with positive microbubble test using transcranial Doppler(TCD).Methods A total of 350 consecutively patients diagnosed as ischemic stroke were included in this study.118 ischemic patients were classified as CS according to TOAST standard.All of them had been examined with microbubble test by using TCD.Clinical characteristics,laboratory indicators and neuroimaging data were collected in retail.Results There were 46 patients with positive microbubble test in 118 CS patients.In which,the average ages were 54.48 years olds and the male paitents were 78.3%.These 46 patients had low prevalence of common risk factors of ccounted for 65.2%.Of which,39 casischemic stroke.However,the incidence rate of hypertension aes(84.8%) were cerebral infarction,including 33 cases(84.6%) with anterior circulate-on infarction and 6 case(15.4%) with posterior circulation infarction);7cases(15.2%) were transient ischemic attack(TIA);5 cases(12.8 %) were with mono lesion and 34 case(87.2 %) were with multiple lesions.For NIHSS score,27 cases(69.2%) scored as 0-3 and 8 cases(20.5%) scored as 4-10 and 4 cases(10.3%)scored as larger than 11.For microbubble scores,39 cases(8-4.8%) were classified as I-II degree while other 7 cases(15.2%) classified as III-IV degree.Conclusion The CS patients with positive micrebubble test is more inclined to young and middle-aged male.Among whom,anterior circulation and multiple lesions infarction were predominated.These patients are likely to have moderate neurological impairments.The common risk factors of stroke are less,but the incidence of hypertension is higher.更多还原