【摘要】 目的:基于肝郁大鼠模型的肝功能与胃肠功能变化,初步探讨"见肝之病,知肝传脾"的客观性,为未病先防,已病防传提供科学依据。方法:SD大鼠16只,雄性,体重(180±20)g,采用随机数字表法分为正常组和模型组,每组8只。采用慢性束缚应激法复制肝郁大鼠模型,观察比较两组大鼠的外观状态、体重增长情况、血清中天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、胃动素(MTL)、胃泌素(GAS)、生长抑素(SS)、胆囊收缩素(CCK)的含量以及尿D-木糖排泄率(UD-x ER)。结果:与正常对照组比较,模型组大鼠体重增长量降低(P<0.05);血清中ALT、AST含量升高(P<0.05),GAS、MTL、CCK含量降低(P<0.05),SS含量升高(P<0.05),尿D-木糖排泄率降低(P<0.05)。结论:肝郁证候的出现常常伴随着脾虚证候,肝脏功能的损伤与胃肠激素的变化、小肠吸收功能的下降密切相关,初步表明"见肝之病,知肝传脾"的客观性。更多还原

【Abstract】 Objective:Based on the change of liver function and gastrointestinal function in rat model with liver depression,preliminarily discuss the objectivity of strengthening spleen when treating liver disease because spleen can be involved in to provide the scientific basis for preventionand transformation.Methods:Sixteen SD male rats,weighted(180 ± 20) g,were randomly assignedinto the normal group and the model group,8 in each.By using chronic restraint stress to establish the rat model of syndrome of stagnation of liver depression to observe the weight and the contents of AST,ALT,MTL,GAS,SS and CCKin serum and UD-x ER between the two groups.Results:Compared with the normol group,the weight of the model group was growing slowly and the difference was statistically significant(P<0.05).The levels of AST and ALT were higher significantly and the difference was statistically significant(P<0.05).The contents of GAS,MTL and CCK had a downward trend(P<0.05).The content of SS was significantly growed(P<0.05) and the level of UD-x ER had a downward trend(P<0.05).Conclusion:The occurrence of stagnation of liver depression syndrome is often accompanied by spleen deficiency syndrome.The damage of liver function is closely related to the change of gastrointestinal hormones.Strengthening spleen when treating liver disease because spleen can be involved in has its existence objectivity更多还原