【摘要】 利用氮氧自由基TEMPO作为功能基团对聚酰胺-胺树枝状大分子进行修饰,通过交联制备出含有TEMPO功能基的纳米粒,并对其结构进行了表征。所合成的含自由基大分子在水溶液中的粒径约为120nm。透射电子显微镜显示纳米颗粒近似为球形,粒径分布较为均一。共价结合到纳米粒中的TEMPO依然保持了顺磁性及对超氧阴离子自由基的清除能力。生物学评价表明,与小分子TEMPO相比,含TEMPO的纳米粒具有较低的细胞毒性。本研究合成的含自由基纳米粒有望用于肿瘤的诊断与治疗。更多还原

【Abstract】 A new kind of free radical-containing dendrimers was synthesized by crosslinked polyamide amine dendrimers with DSP and modified with TEMPO and THPA.The average hydrodynamic size of the product is about 120 nm.Transmission electron microscopy shows that the nanoparticles are spherical and the particle size distribution is narrow.The denrimers covalently bounded with TEMPO shows paramagnetic and quasi SOD activity.Compared with TEMPO,TEMPO-containing nanoparticles have low cytotoxicity.Therefore,these nanoparticles could be used as a potential nano-biomaterial applied in the field of diagnosis and cancer therapy.更多还原