严重创伤患者医院感染铜绿假单胞菌的分布与耐药性分析

【摘要】 目的 了解严重创伤患者医院感染铜绿假单胞菌的耐药性特点,为临床合理使用抗菌药物提供参考依据。方法 对2011年12月至2016年11月重症监护病房(ICU)住院严重创伤患者送检的痰液、血液、尿液、体液、脓液、留置物等标本进行病原菌培养、鉴定和药敏试验,统计分析铜绿假单胞菌分离菌株数及对常规抗菌药物敏感率。结果 2011年12月至2016年11月ICU严重创伤患者送检标本分离铜绿假单胞菌173株,有逐年增多趋势,医院感染的高发部位主要是呼吸道、泌尿道、皮肤黏膜,分别占54.34%、20.81%、10.98%;各年度铜绿假单胞菌对头孢派酮/舒巴坦、头孢吡肟、妥布霉素有较高敏感率,敏感率>50%,对其它抗菌药物有不同程度的耐药。结论 ICU严重创伤患者是铜绿假单胞菌感染的高发区,其耐药现象日趋严重,要加强细菌检测和用药监管,扭转铜绿假单胞菌耐药性无序增长的不良局面。更多还原

【Abstract】 Objective To understand the characteristics of drug resistance of Pseudomonas aeruginosa in nosocomial infection in patients with severe trauma, and provide reference for clinical rational use of antimicrobial agents. Method From December 2011 to November 2016, ICU for patients with severe trauma in the sputum, urine, blood, body fluid, pus, liens and other samples were pathogenic bacteria cultured, identification and drug sensitivity test, statistical analysis of Pseudomonas aeruginosa strains and antimicrobial drug sensitive rate of routine were measured. Results From December 2011 to November 2016, ICU in patients with severe trauma were collected from 173 strains of Pseudomonas aeruginosa, increased year by year. High risk sites of nosocomial infection was mainly in respiratory tract, urinary tract, skin and mucous membrane, accounted for 54.34%, 20.81%,10.98%. Each year the Pseudomonas aeruginosa had a Gao Min rate of Cefoperazone/Shubatan, cefepime, tobramycin, >50% sensitive rate, had varying degrees of resistance to other antibacterial drugs. Conclusion Severe trauma patients in ICU are Pseudomonas aeruginosa infection in high incidence area, its resistance is becoming more and more serious. To strengthen the detection of bacteria, drug administration, adverse situation to reverse the drug resistance of Pseudomonas aeruginosa disorderly growth.更多还原