【摘要】 目的 探讨氯沙坦对慢性肺心痛心力衰竭患者右心室Tei指数与血浆N-末端脑钠肽前体(NT-proBNP)水平的影响。方法 慢性肺心病心力衰竭患者120例,随机分为两组,即氯沙坦组(60例)和对照组(60例)。对照组仅接受常规治疗,氯沙坦组在常规治疗基础上给予氯沙坦50mg/d。检测两组治疗前及治疗6个月后右心室Tei指数与血浆NT-pro-BNP水平变化。结果 肺心痛心力衰竭患者右心室Tei指数与血浆NT-proBNP水平呈正相关。治疗6个月后,两组右心室Tei指数、NT-pro-BNP水平较治疗前均有所下降,差异有统计学意义(P<0.05,P<0.01),但氯沙坦组下降更为显著,两组比较差异有统计学意义(P<0.01)。结论 氯沙坦能有效降低右心室Tei指数和血浆NT-pro-BNP水平,改善肺心病患者的心功能,这与氯沙坦能阻抑心室重构,改善心肌顺应性有关。更多还原

【Abstract】 Objective Explore the effect of Losartan on right ventricular Tei index and N-terminal brain natriuretic peptide precursor(NTproBNP) in patients with Chronic cor pulmonale heart failure.Methods 120 patients with chronic cor pulmonale heart failure were randomly divided into two groups:the Losartan group(60 cases) and the control group(60 cases).The control group only accepted routine treatment,and Losartan group on the basis of routine therapy for Losartan 50 mg/d.The Tei index and NT-pro-BNP were detected in the two groups before and after 6 months.Result The right ventricular Tei index were positively correlated with the level of NT-proBNP in patients with chronic cor pulmonale heart failure.The Tei index and the NT-proBNP level were significantly decreased 6 months after treatment than those before treatment in two groups(P<0.05,P<0.01),but the Losartan group decreased more significantly.The difference between the two groups was statistically significant(P<0.01).Conclusions Losartan can effectively reduce the right ventricular Tei index and NT-proBNP levels,and improve heart function in patients with Chronic cor pulmonale,this may be associated with Losartan obstructing the ventricular remodeling and improving myocardial compliance.更多还原