药物致获得性维生素K依赖性凝血因子缺乏症分析

【摘要】 目的 探讨药物致获得性维生素K依赖性凝血因子缺乏症的病因和安全医疗。方法 回顾性分析本院治疗25例药物致获得性维生素K依赖性凝血因子缺乏症患者的病因、临床特点、治疗、误诊原因和随访结果。结果 药物致获得性维生素K依赖性凝血因子缺乏症可出现程度不一的出血表现。病因以杀鼠药中毒最为常见,普通患者予每日维生素K1针20~30mg治疗有效,严重的患者在此基础上联合新鲜冰冻血浆和凝血酶原复合物治疗可有效控制。结论 药物致获得性维生素K依赖性凝血因子缺乏症早期治疗效果显著,建议初始治疗予以常规剂量维生素K1。更多还原

【Abstract】 Objective To investigate the etiology and safety medical of drug-induced acquired deficiencies of vitamin K-dependent coagulation factors.Method Retrospective analysis was performed on the etiologies,clinical characteristics,treatment responses,misdiagnosis reasons and follow-up results of the drug-induced acquired deficiencies of vitamin K-dependent coagulation factors.Result The patients of drug-induced acquired deficiencies of vitamin K-dependent coagulation factors could occur varying severely bleeding.The most common cause wasanticoagulant rodenticides poisoning.Moderate patients could be treated by injection of vitamin K1 20-30 mg per-day,severely patients needed additional of Fresh frozen plasma and prothrombin complex.Conclusion The early treatment of drug-induced acquired deficiencies of vitamin K-dependent coagulation factors is effective.We suggest initial therapy by conventional doses of vitamin K1.更多还原