【摘要】 目的:阐述药源性肾损伤的病理机制和临床特征,探讨其发生影响因素,以及此类病例的处理措施和药学监护重点,为预防和避免药源性肾损伤的发生提供临床参考。方法:收集2016年4月至2017年4月北京大学第三医院肾脏内科的典型药源性肾损害病例。结果:共发生6例典型的由药物引起的肾损伤案例,包括阿德福韦酯致范可尼综合征1例,阿托伐他汀钙致横纹肌溶解伴急性肾损伤1例,穿心莲内酯致急性肾小管间质损伤2例,别嘌醇致药物超敏反应综合征1例,非甾体抗炎药致急性肾损伤1例。结论:药源性肾损伤问题日益突出,需引起临床重视,以便及早进行预防和治疗。更多还原

【Abstract】 Objective: To elucidate the pathogenesis, clinical characteristics, risk factors, treatment measures and pharmaceutical monitoring of drug-induced kidney injury(DIKI), aiming to provide useful information and evidences to reduce the incidence of DIKI in the future. Methods: The typical cases of DIKI that happened at the Peking University Third Hospital from April 2016 to April 2017 were collected. Results: Six cases of DIKI were identified, including adefovir dipivoxil-induced fanconi syndrome, atorvastatin-induced rhabdomyolysis, and 2 cases of rographolide-induced acute renal tubulointerstitial injury, allopurinol-induced hypersensitivity syndrome,and nonsteroidal anti-inflammatory drugs(NSAIDs)-induced acute kidney disease. Conclusion: The prevalence of DIKI has gradually increased in recent years. More attention should be paid to this issue to ensure the early prevention and treatment of such cases.更多还原