Objective:To explore the feasibility of making acute myocardial infarction model in Beagle dog by microspheres combined with thrombin powder through femoral artery intervention.Method:The 32 Beagle dogs(ages 10-13 months),with male and female in half,were punctured femoral artery to make coronary angiography,and rapid injected polyethylene microspheres 2 ml(4×104/ml)into left anterior descending coronary artery by microcatheter.Then they were injected with thrombin powder 2 ml(1000 u/ml)to make myocardial i...