【摘要】 目的观察小剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎(CRS)的临床疗效。方法将129例CRS患者按治疗方法的不同分为3组。A组43例,采用克拉霉素片治疗;B组42例,采用布地奈德鼻喷雾剂治疗;C组44例,采用克拉霉素片联合布地奈德鼻喷雾剂治疗。观察3组治疗前、治疗12周后鼻部症状(鼻塞、流涕、头痛、嗅觉减退)评分、鼻窦Lund-Mackay评分及临床疗效。结果 C组总有效率明显高于A、B 2组(88.64%比67.44%、71.43%,均P<0.05)。与治疗前比较,3组治疗12周后鼻塞、流涕、头痛、嗅觉减退评分和鼻窦Lund-Mackay评分均明显下降(均P<0.05);与A、B 2组比较,C组治疗12周后鼻塞、流涕、头痛、嗅觉减退评分和鼻窦Lund-Mackay评分均下降更明显(均P<0.05)。结论小剂量克拉霉素联合鼻用激素治疗CRS疗效确切,可改善患者的鼻部症状。更多还原

【Abstract】 Objective To observe the clinical effect of small-dose clarithromycin combined with nasal steroid on chronic rhinosinusitis(CRS).Methods A total of 129 patients with CRS were treated with clarithromycin tablets(group A,n=43),budesonide nasal spray(group B,n=42),or their combination(group C,n=44).The nasal symptoms(rhinobyon,runny nose,headache and hyposmia)score,Lund-Mackay sinus CT score and clinical efficacy were observed before and after treatment for 12 weeks.Results The total effective rate in group C(88.64%)was significantly higher than that in group A(67.44%)or group B(71.43%)(P<0.05).After treatment for 12 weeks,the VAS of nasal symptoms and Lund-Mackay sinus CT score significantly decreased in all the three groups(P<0.05).Furthermore,the decrease in group C was more obvious than that in group A or group B(P<0.05).Conclusion The small-dose clarithromycin combined with nasal steroid can effectively treat CRS and improve nasal symptoms.更多还原