【摘要】 目的 探讨帕金森病患者认知功能障碍及其相关危险因素。方法对73例帕金森病患者采用自拟调查问卷统计一般资料,采用帕金森病统一评价量表评定日常生活能力及运动功能,蒙特利尔认知评估量表评定认知功能,汉密顿抑郁量表评定抑郁状况,Hoehn-Yahr分级量及评定病情严重程度,检测血尿酸水平,对认知功能障碍的危险因素进行多因素Logistic回归分析。结果 本组患者认知功能障碍发生率为69.9%,存在认知功能障碍患者受教育程度、血尿酸水平显著低于无认知功能障碍患者(P〈0.01),病程、汉密顿抑郁量表总分、Hoehn-Yahr分级、帕金森病统一评价量表-Ⅱ总分、帕金森病统一评价量表-Ⅲ总分均显著高于无认知功能障碍者(P〈0.05或0.01);患者发生认知功能障碍与其受教育程度、病程长短、Hoehn-Yahr分级、帕金森病统一评价量表-Ⅲ总分、汉密顿抑郁量表总分关系密切(P<0.05或0.01)。结论 帕金森病患者认知功能障碍发生率高,患者的受教育程度、病程、抑郁状况、病情严重程度以及运动功能状况等与其发生认知功能障碍显著相关,可能是其发生认知功能障碍的独立危险因素。帕金森病统一评价量表;蒙特利尔认知评价量表;汉密顿抑郁量表;Hoehn-Your分量表;尿酸更多还原

【Abstract】 Objective To explore the cognitive dysfunction in patients with Parkinson’s disease and related risk factors. Methods To statistic common data of 73 cases Parkinson’s patients by the questionnaire, adopts the unified Parkinson’s disease assessment scale to assess the daily life ability, and motor function,Montreal cognitive assessment scale to assess cognitive function, Hamilton depression scale to assess depression status, Hocehn-Yahr severity rating scale to assess their condition, Serum uric acid(UA) levels were detected. Then a multifactor Logistic regression analysis was performed for the risk factors of cognitive dysfunction. Results The cognitive dysfunction rate was 69. 9%. The degree of education and UA in patients with cognitive dysfunction was significantly lower than that of patients without cognitive dysfunction(P< 0.01). The course of diseases, HAMD scores. Hoehn-Yahr stage, UPDRS II total score, the UPDRS III with scores were significantly higher than that of no cognitive impairment patients(P< 0. 05 or 0.01); The degree of education, pathogenesis,depression, severity,and motor function of patients were significantly correlated with their cognitive impairment(P< 0. 05 or 0. 01). Conclusion It occurs a significant relation between the education, the course of the disease, depression, illness severity and movement function conditions with cognitive dysfunction, which may be the independent risk factors of cognitive dysfunction.更多还原