【摘要】 目的 探讨慢性阻塞性肺疾病继发肺动脉高压患者与血清中内皮素-1、C反应蛋白及肿瘤坏死因子α的相关性。方法 对68例慢性阻塞性肺疾病继发肺动脉高压患者(PH组)、56例非继发肺动脉高压患者(非PH组)及60名健康志愿者(对照组)采集空腹静脉血进行血清内皮素-1、C反应蛋白及肿瘤坏死因子α检测分析。结果 慢性阻塞性肺疾病患者中PH组和非PH组血清中内皮素-1、C反应蛋白及肿瘤坏死因子α的表达水平均显著高于对照组(P<0.05或(0.01),且PH组患者均显著高于非PH组(P<0.05)。平均肺动脉收缩压与血清中内皮素-1、C反应蛋白及肿瘤坏死因子α表达水平均呈显著正相关(r=0.526、0.437、0.502,P<0.05);慢性阻塞性肺疾病患者血清中内皮素-1的表达与C反应蛋白及肿瘤坏死因子α表达水平均呈显著正相关(r=0.451、0.378,P<0.05),C反应蛋白的表达与肿瘤坏死因子《表达水平也呈显著正相关(r=0.4 7 2.P<0.0 5)。结论 慢性阻塞性肺疾病继发肺动脉高压患者存在血清中内皮素-1、C反应蛋白及肿瘤坏死因子《因子表达的上调,联合监测上述因子有利于继发肺动脉高压患者的早期监控以及病变程度的评估。更多还原

【Abstract】 Objective To investigate the correlation between pulmonary hypertension and endothelin-1(ET-1). C-reactive protein(CRP), tumor necrosis factor-a( TNF-α) in patients with chronic obstructive pulmonary disease. Methods A total of 124 cases of COPD patients with PH were enrolled in this study.COPD patients were divided into two groups: PH group(n= 68) and non-PH group(n = 56). Another 60 healthy person were used as a normal control. Fasting blood was collected for detection and analysis of ET-1, CRP and TNF-α. Results The serum levels of ET-1, CRP and TNF-a were higher in PH and non-PH group than that in normal control(P<0. 05 or 0. 01). Which was higher in PH group than that in nonPH group(P<0. 05). The average pulmonary arterial systolic pressure was positively related with serum levels of ET-1 CRP and TNF-α(r = 0. 526、0. 437、0. 502.P<0. 05). The serum levels of ET-1 was positively related with CRP and TNF-α(r-0. 451 、0. 378,P<0. 05). The serum levels of CRP was positively related with TNF-α(r= 0.472, P<0. 05). Conclusion The high-level expression of ET-1, CRP and TNF-α are found in COPD combined with PH patients. Combined monitoring of the above factors benefits for early control and assessment of disease degree in patients with pulmonary hypertension.更多还原