【摘要】 目的 探究经皮冠状动脉介入手术对老年冠心病患者左心功能改善及血清纤溶酶原激活物抑制剂-1、C反应蛋白、肌钙蛋白水平的影响。方法 将86例老年冠心病患者根据不同治疗方法分为两组,每组43例,观察组给予经皮冠状动脉介入手术治疗,对照组给予常规药物保守治疗,观察两组手术前后左心功能指标及血清纤溶酶原激活物抑制剂-1、C反应蛋白、肌钙蛋白水平。结果 手术前两组左心射血分数、左心室收缩未、室舒张未容积比较差异无统计学意义(P>0.05);术后两组左心射血分数较手术前显著升高,观察组显著高于对照组(P<0.01);左心室收缩末、室舒张末容积均小于手术前,观察组显著小于对照组(P<0.01)。手术前两组血清纤溶酶原激活物抑制剂-1、C反应蛋白、肌钙蛋白水平比较差异无统计学意义(P>0.05);手术后两组血清纤溶酶原激活物抑制剂-1、C反应蛋白、肌钙蛋白水平均显著低于手术前(P<0.05或0.01),观察组显著低于对照组(P<0.01)。结论 经皮冠状动脉介入手术可有效改善老年冠心病患者左心功能,降低血清纤溶酶原激活物抑制剂-1、C反应蛋白、肌钙蛋白水平,在临床治疗中具有重要意义。更多还原

【Abstract】 Objective To investigate the effect of percutaneous coronary intervention on left ventricular function and serum plasminogen activator inhibitor-1, C-reactive protein and troponin levels in elderly patients with coronary heart disease. Methods 86 elderly patients with coronary heart disease were recruited and evenly divided into study group and control group according to different treatment methods. The patients in study group were given percutaneous coronary intervention, while the patients in control group were conservatively administrated with conventional medicine. The levels of left ventricular function index and serum PAI-1,CRP,cTnI before and after treatment were detected in both groups. Results Before treatment, the LVESV, LVEF and LVEDV in two groups were not significantly different(P>0. 05);After treatment, the LVEF in two groups increased, and its level in study group was significantly higher than that in control group(P<0. 01); LVESV and LVEDV were comparatively lower, and the levels in study group were significantly lower than those in control group(P<0. 01). Before treatment, the serum PAI-1, CRP and cTnI levels in two groups were not significantly different(P>0. 05); after treatment, the serum PAI-1, CRP and cTnI levels in two groups significantly decreased(P<0. 05 or 0.01), and the the levels in study group were significantly lower than those in control group(P<0. 01). Conclusion Percutaneous coronary intervention can effectively improve the left ventricular function in elderly CHD patients,and reduce the serum PAI-1, CRP and cTnl levels, is of great clinical value for the CHD treatment.更多还原