【摘要】 脑胶质瘤尤其是低级别胶质瘤通常会以癫为起病症状,称为肿瘤相关性癫(TRE)。对TRE的治疗是神经外科面临的重大难题,目前对于TRE的发生和发展机制研究还不够透彻,对其的理解还不够深入。文内归纳了TRE可能机制的相关文献,包括肿瘤自身和肿瘤周边的因素、肿瘤部位、组织学类型、基因等方面的改变,肿瘤周边的神经递质、离子、受体、细胞因子、微环境改变都为TRE的发生发展创造了条件。脑神经网络的改变可以更好地解释癫发作对脑功能系统性变化的影响。了解这些机制将对TRE治疗有一定帮助。更多还原

【Abstract】 Many patients with glioma present seizure as the initial symptom, especially with low grade glioma. Seizures play an important role in the quality of life. Despite the importance of tumor-related epilepsy to neurosurgery, its pathogenesis remains unclear. The possible mechanism of tumor-related epilepsy was summarized, including both tumoral and peritumoral aspects. The location, histology, tight junction, and gene mutation were included in tumoral aspects. Ions, neurotransmitter, receptor, cytokine and microenvironment play important roles in peritumoral aspects. Changes in the brain network can be used to explain seizure how to alter the whole brain function better, which may help doctor search for new strategies in the treatment for tumor related epilepsy.更多还原