【摘要】 目的:探讨嗜酸性粒细胞增多性皮炎(HED)的诊断及治疗策略。方法:对2011年1月—2015年8月该院30例HED住院患者的临床资料进行回顾性分析并随访。结果:30例患者男女比为1.73∶1,平均年龄55.2岁。皮损特点为泛发性及多形性损害,伴剧痒。血常规和骨髓细胞学均显示嗜酸性粒细胞增多。皮损组织病理检查示真皮层见以嗜酸性粒细胞及淋巴细胞为主的炎性细胞浸润。在口服抗组胺药物基础上,予单用小、中剂量糖皮质激素或联合免疫抑制剂治疗效果最佳。结论:糖皮质激素联合抗组胺药为HED治疗首选药物,联合应用免疫抑制剂有协同作用。更多还原

【Abstract】 Objective: To explore the diagnosis and therapeutic strategies for hypereosinophilic dermatitis(HED). Methods:Clinical data of 30 in-patients with HED from January 2011 to August 2015 were retrospectively analyzed and followed-up.Results: The ratio of male to female was 1.73∶1. The average age of onset was 55.2 years old. Lesions were manifested by generalized, pruritic polymorphous lesions. Both blood and bone marrow cytology showed eosinophilia. Pathological examination showed inflammatory infiltration of eosinophils and lymphocytes in the dermis. In addition to antihistamine,low to medium dose of glucocorticoids alone or in combination with immunosuppressor were effective. Conclusion: Combination of glucocorticoids with antihistamine is the first choice for HED. Combination of this regimen with immunosuppressor can achieve synergic benefit.更多还原