【摘要】 目的:探讨血清白介素6(IL-6)水平与抑郁发作的关系。方法:检测及比较单相抑郁障碍63例(单相抑郁组)、双相障碍抑郁80例(双相抑郁组)及健康对照者42名(对照组)血清IL-6水平;采用汉密尔顿抑郁量表(HAMD)评定单相与双相抑郁发作患者抑郁症状,分析血清IL-6水平与HAMD评分的关系。结果:病例组和对照组血清IL-6水平分别为(64.56±7.10)ng/L和(22.54±2.99)ng/L,两组组间差异具有统计学意义(F=1362.51,P<0.01)。单相抑郁组和双相抑郁组血清IL-6水平分别为(65.11±7.21)ng/L和(63.85±6.95)ng/L,两组间差异无统计学意义(P>0.05)。抑郁发作患者血清IL-6水平与HAMD评分呈正相关(r=0.19,P=0.025)。结论:单相与双相抑郁发作患者血清IL-6水平显著升高,并与其病情的严重程度一致。更多还原

【Abstract】 Objective: To investigate the relationship between serum IL-6 protein and unipolar depression as well as bipolar depression. Method: 143 patients with depressive episode,including 63 ones with unipolar depression( unipolar group) and 80 ones with bipolar depression( bipolar group),and 42 healthy controls( control group) were enrolled. Depressive symptoms were evaluated using Hamilton rating scale for depression( HAMD) and serum IL-6 levels were measured. Results: IL6 levels in case and control groups were( 64. 56 ±7. 10) ng/L and( 22. 54 ± 2. 99) ng/L,respectively. There was significant difference in IL6 levels between these groups( F = 1362. 51,P < 0. 01). IL6 levels in unipolar and bipolar groups were( 65. 11 ± 7. 21) ng/L and( 63. 85 ± 6. 95) ng/L. There were no significant difference in IL6 levels between the unipolar and bipolar groups( P > 0. 05). There was a positive correlation between the serum level of IL6 and HAMD total score in patients with depressive episode( r = 0. 19,P = 0. 025). Conclusion: Serum IL-6 levels increase in patients with unipolar or bipolar depression and correlate with severity of depression.更多还原