【摘要】 慢性HCV感染是肝纤维化、肝硬化及肝细胞癌的重要发病原因。胰岛素抵抗(IR)是HCV感染的重要病理学特征之一。IR可加速肝纤维化、肝脂肪变性、肝细胞癌的发病进程,而且影响抗病毒治疗的效果,因此,HCV相关性IR在HCV感染的任何阶段都可作为药物治疗的靶点。综述了丙型肝炎患者并发IR的发病机制,两者间的相互作用,以及IR对抗病毒治疗的影响。更多还原

【Abstract】 Chronic hepatitis C virus(HCV) infection is an important cause of hepatic fibrosis,liver cirrhosis,and hepatocellular carcinoma(HCC). Insulin resistance(IR) is one of the important pathological features of HCV infection. IR can accelerate the development of hepatic fibrosis,hepatic steatosis,and HCC and affect the efficacy of antiviral therapy. Therefore,HCV-related IR can be the target of pharmacotherapy during any stage of HCV infection. This article reviews the pathogenesis of IR in patients with hepatitis C,the interaction between them,and the impact of IR on antiviral therapy.更多还原