【摘要】 目的:检测RAGE、RECK在涎腺多形性腺瘤(pleomorphic adenoma,PA)初发、复发和恶变中的表达情况及临床意义。方法:免疫组化法分别检测正常13例,PA初发36例、复发8例,恶变10例涎腺组织RAGE及RECK的表达情况,分析其表达的差异性,并探讨其相关性。结果:RAGE在正常、初发、复发及恶变标本中阳性表达率分别为:15.40%、41.70%、62.50%、90.00%,呈逐渐升高的趋势,并且在阳性率和表达强度比较发现,正常、初发组均明显低于复发及恶变组,差异具有统计学意义(P<0.05)。RECK在正常、初发、复发及恶变标本中阳性表达率分别为:76.90%、55.60%、37.50%、20.00%,呈逐渐降低的趋势,并且在阳性率和表达强度比较发现,正常、初发组均明显高于复发及恶变组,差异具有统计学意义(P<0.05)。RAGE和RECK在各组中的表达呈负相关性(r=-0.512,P<0.05)。结论:本研究结果可能进一步阐述多形性腺瘤复发及恶变的发病机制,为辅助预测患者预后及为患者的综合治疗提供参考。更多还原

【Abstract】 Objective:To detect the expressions of RECK and RAGE in incipient,recurrent,and malignant pleomorphic adenoma(PA)of salivary glands,and to study their clinical significance.Methods:Immunohistochemical staining was used to detect the expressions of RECK and RAGE in four groups,13 cases with normal salivary gland tissue,36 cases with incipient PA,8cases with recurrent PA,10 cases with Malignant transformation.The differences of RECK and RAGE expressions were analyzed and their correlation was investigated.Results:The positive expression rates of RAGE were 15.40%,41.70%,62.50%,and 90.00% respectively,which increased from the normal gland group to the malignant group.The positive expression rates and intensity of RAGE in the normal and incipient group were significantly lower than those in the recurrent and malignant group(P<0.05).The positive expression rates of RECK in the four groups were 76.90%,55.60%,37.50%,and 20.00% respectively,which decreased from the first group to the last group.The positive expression rate and intensity of RECK in the normal and incipiant group were significantly higher than those in the recurrent and malignant groups(P<0.05).Correlation analysis showed that the expression of RAGE and RECK were negatively correlated in four groups(r=-0.512,P<0.05).Conclusion:It might be beneficial to understand the pathogenesis of recurrence and malignant transformation of PA,and might provide reference for patient’s prognosis and for comprehensive treatments.更多还原