【摘要】 目的探讨白细胞介素6(IL-6)基因-572C/G多态与遵义汉族混合型高脂血症的相关性。方法用聚合酶链反应产物直接测序分析100例混合型高脂血症患者和100例正常对照者IL-6基因-572C/G多态性。结果混合型高脂血症组和正常对照组年龄、性别、血糖差异无统计学意义(P>0.05),混合型高脂血症组血脂指标明显高于正常对照组(P<0.05);IL-6基因-572C/G基因型频率和等位基因频率在混合型高脂血症组与正常对照组间差异无统计学意义(P>0.05);总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、甘油三酯(TG)/高密度脂蛋白胆固醇(HDLC)和TC/HDLC值在正常对照组组内CC与CG+GG基因型个体间差异具有统计学意义(P<0.05);两组内其他血脂指标无统计学差异(P>0.05)。结论 IL-6基因-572C/G多态与遵义汉族人群混合型高脂血症发病不存在相关性;IL-6基因-572G等位基因不是混合型高脂血症的独立危险因素。更多还原

【Abstract】 Aim To investigate the relativity of interleukin-6 gene-572C/G polymorphism with combined hyperlipidemia in Zunyi Han Nationality. Methods-572C/G polymorphism of 100 combined hyperlipidemia patients and100 healthy individuals were tested by sequencing after polymerase chain reaction. Results Age,gender and blood sugar had no statistical differences between patients group and normal group,but blood lipid index of combined hyperlipidemia patients was higher than healthy individuals( P< 0.05). The genotype frequency and allele gene frequency of IL-6gene-572C/G showed no correlation between patients group and normal groups( P>0.05). Total cholesterol( TC),low density lipoprotein cholesterol( LDLC),triglyceride( TG)/high density lipoprotein cholesterol( HDLC) and TC/HDLC were different between CC and CG+GG genotype in the normal group( P< 0.05); others had no differences among the two groups. Conclusion There was no relativity between IL-6 gene-572C/G polymorphism and combined hyperlipidemia in Zunyi Han Nationality. The-572 G gene was not an independent risk factor for combined hyperlipidemia.更多还原