【摘要】 成纤维细胞生长因子21(FGF21)主要参与糖脂代谢的调节,与肥胖、糖尿病、代谢综合征和非酒精性脂肪肝等多种疾病或病理过程密切相关。目前研究表明,FGF21可以拮抗心肌缺血和缺血再灌注损伤,发挥明显的心肌保护作用,其作用机制可能与抗心肌细胞凋亡、抗炎、抗氧化应激、调节心肌细胞能量代谢和线粒体功能等有关。本综述简要概括FGF21心肌保护作用及其机制的研究进展。更多还原

【Abstract】 Fibroblast growth factor 21( FGF21) is involved in the regulation of glucose and lipid metabolism,and is closely related to obesity,diabetes,metabolic syndrome,nonalcoholic fatty liver disease and other diseases or pathological processes. The present studies show that FGF21 can antagonize myocardial ischemia and ischemia reperfusion injury,play a significant role in myocardial protection,and its mechanism may be related to anti-apoptosis of cardiomyocyte,antiinflammation,anti-oxidative stress,regulation of myocardial cell energy metabolism and mitochondrial function,and so on.This review summarizes the research progress of myocardial protective effect of FGF21 and its mechanism.更多还原