【摘要】 目的探讨冠心病患者血浆Adropin蛋白与同型半胱氨酸(Hcy)水平的相关性,以及二者与冠心病病情严重程度的关系。方法选取2014年5月至2016年5月该院收治的170例冠心病患者作为研究对象,收集患者外周血检测血浆Adropin蛋白、Hcy和其他常规生化指标。冠状动脉造影确立患者冠状动脉病变情况,冠状动脉病变严重度用SYNTAX评分表示。结果170例患者平均Hcy水平为(15.92±8.31)μmol/L,76例(44.7%)伴高同型半胱氨酸血症(Hcy>15μmol/L),高Hcy组Aropin蛋白水平低于非高Hcy组,体质量指数、SYNTAX评分和肌酐水平均高于非高Hcy组,差异均有统计学意义(P<0.05)。所有患者平均SYNTAX评分为(21.51±11.20)分,血浆Adropin蛋白与Hcy水平呈负相关(r=-0.169,P=0.028),血浆Hcy水平与SYNTAX评分无明显相关性(r=0.124,P=0.108),Adropin蛋白与SYNTAX评分呈负相关(r=-0.181,P=0.018)。广义结构方程模型显示,随着Adropin蛋白水平降低,SYNTAX评分则增加(P=0.019),与不伴高Hcy患者比较,伴高Hcy患者SYNTAX评分更高(P=0.005)。结论冠心病患者血浆Adropin蛋白与Hcy水平呈负相关,Adropin蛋白越低,Hcy水平越高,冠状动脉病变程度越严重。更多还原

【Abstract】 Objective To investigate the correlation between plasma adropin and homocysteine(Hcy)levels in patients with coronary artery disease,and discuss their relationship with disease severity of coronary heart disease.Methods 170 cases of patients with coronary artery disease were collected from May 2014 to May 2016 in the hospital,peripheral blood was collected for measuring plasma adropin,homocysteine(Hcy)and other conventional biochemical indicators,coronary artery lesions were detected by coronary angiography,and the severity of coronary artery disease was assessed by SYNTAX score.Results The average serum homocysteine level of 170 patients was(15.92±8.31)μmol/L,and 76(44.7%)patients were identified as Hyperhomocysteinemia with a serum homocysteine level>15μmol/L.The level of adropin in high Hcy group was lower than that of non-high Hcy group,and BMI index,SYNTAX scores and creatinine levels in high Hcy group were higher than those of non-high Hcy group,and the differences were statistically significant(P<0.05).The average SYNTAX score of all patients was(21.51±11.20),plasma adropin level was negatively correlated with Hcy level(r=-0.169,P=0.028),Hcy level had no significant correlation with SYNTAX score(r=0.124,P=0.108),and plasma adropin level was negatively correlated with SYNTAX score(r=-0.181,P=0.018).Generalized structural equation model shows that with the decrease of plasma adropin level,SYNTAX score was increased(P=0.019).Patients with hyperhomocysteinemia had a significantly higher average SYNTAX score compared with those without hyperhomocysteinemia(P=0.005).Conclusion Adropin level was negatively correlated with homocysteine(Hcy)level in patients with coronary heart disease.,The lower of the adropin level,the higher of Hcy level,the more severe situation of coronary artery disease.更多还原