【摘要】 目的探讨同型半胱氨酸(Hcy)、C反应蛋白(CRP)及血清脂质的检测对2型糖尿病患者的诊断及预后评估价值。方法选取2014年8月至2016年4月该院收治的2型糖尿病患者98例为观察组,另选取同时期在该院进行健康体检者60例为对照组,应用循环酶法对2组患者的Hcy水平进行检测,采用免疫透射比浊法检测CRP、载脂蛋白A(APOA)、载脂蛋白B(APOB)的水平,采用酶法对血清三酰甘油(TG)水平进行检测,并对比2组各指标的差异。结果与对照组对比,观察组患者的血浆Hcy水平及血清CRP水平均显著升高,差异有统计学意义(P<0.05);与对照组对比,观察组患者的血清APOA水平显著降低,APOB及TG水平显著升高,差异有统计学意义(P<0.05);Hcy、CRP、APOB、TG与2型糖尿病的发生呈正相关关系,差异有统计学意义(P<0.05);APOA与糖尿病的发生呈负相关关系,差异有统计学意义(P<0.05)。结论 Hcy、CRP及血清脂质相关指标与2型糖尿病的发生及发展具有显著相关性,对2型糖尿病的诊断及预后评估均具有重要价值。更多还原

【Abstract】 Objective To investigate the diagnostic and prognostic value of homocysteine(Hcy),C-reactive protien(CRP)and serum lipid in the patients with type 2diabetes mellitus(T2DM).Methods Ninety-eight patients with T2DM in the hospital from August 2014 to April 2016 were selected as the observation group,and other contemporaneous 60 individuals undergoing healthy physical examination were selected as the control group.The cyclic enzymatic method was used to detect Hcy level in the two groups,the immunoturbidimetric assay was adopted to detect CRP,apolipoprotein a(APOA)and apolipoprotein B(APOB)levels and the enzymatic method was used to detect serum triglyceride(TG)level.Then the differences of various indexes were compared between the two groups.Results Compared with the control group,the level of plasma Hcy and level of serum CRP in the observation group were significantly increased,the difference was statistically significant(P<0.05);compared with the control group,the serum APOA level in the observation group was significantly decreased,the APOB and TG levels were significantly increased,the differences were statistically significant(P<0.05);Hcy,CRP,APOB and TG and were positively correlated with the T2DM onset(P<0.05),while APOA was negatively correlated with the diabetic onset,the differences were statistically significant(P<0.05).Conclusion Hcy,CRP and serum lipid related indicators have significant correlation with the occurrence and development of T2DM,and have an important value for the diagnosis and prognosis of T2DM.更多还原