【摘要】 目的:观察急性心肌梗死(acute myocardial infarction,AMI)患者治疗前后、不稳定心绞痛(unsteadiness angina,UA)患者血清中IL-8,TNF-α,IL-10浓度的变化并评价其临床意义。方法:采用ELISA方法,测定24例急性心肌梗死患者(AMI组),20例不稳定型心绞痛患者(UA组)及24例健康对照组(NC组)血清IL-8,TNF-α,IL-10的浓度。对AMI患者进行药物治疗,分别测定1,6周后患者血清IL-8,TNF-α,IL-10浓度。结果:UA组血清中IL-8,TNF-α,IL-10水平显著高于NC组(分别P<0.01,P<0.01,P<0.05);AMI组血清IL-8,TNF-α,IL-10的水平又显著高于UA组,差异有统计学意义(P均<0.01)。对AMI患者进行药物治疗1周后,血清IL-8,TNF-α,IL-10的水平较治疗前显著降低,差异有统计学意义(分别为P<0.01,P<0.05,P<0.01),AMT患者药物治疗6周后,血清IL-8,TNF-α,IL-10进一步显著降低,与药物治疗1周后相比,差异均有显著统计学意义(P<0.05)。结论:冠心病发病与IL-8,TNF-α,IL-10密切相关,随着心肌缺血损伤的加重,血清IL-8,TNF-α,IL-10水平显著升高;随着病情的缓解,三者水平显著降低,其水平变化与临床病情轻重程度相一致。因此检测血清中的IL-8,TNF-α,IL-10水平作为冠心病诊断、病情评估及治疗效果有重要的临床价值。更多还原

【Abstract】 Objective Observation of acute myocardial infarction( acute myocardial,infarction,AMI) before and after treatment in patients with unstable angina pectoris( unsteadiness,angina,IL-8,UA) in the serum of patients with TNF-α,and to evaluate the clinical significance of the change of IL-10 concentration. Method ELISA method was used to measure the concentration of serum IL-8,TNF-α and IL-10 in 24 patients with acute myocardial infarction( AMI group),20 patients with unstable angina pectoris( UA group) and 24 healthy controls( group NC). Patients with AMI were treated with drugs,and serum IL-8,TNF-α and IL-10 concentrations were measured at 1 and 6 weeks,respectively. Results The concentrations of serum IL-8,TNF-α,IL-10 from patient of UA group were much higher than the patients from NC group( P < 0. 01,P < 0. 01,P < 0. 05,respectively). However,serum levels of IL-8,TNF-α,IL-10 from AMI group are much higher than UA group( all P < 0. 01). And serum level of IL-8,TNF-α,IL-10 from AMI patients with one week’s treatment was obviously lower than the serum levels from AMI patients before treatment( P < 0. 01,P < 0. 05,P < 0. 01,respectively). Serum concentration of these indicatored become lower and lower after 6 week’ s treatment. The difference had significance comparing the AMI patients with one week treatment( P < 0. 05). Conclusion IL-8,TNF-α,IL-10 have close relationship with CAD,the concentration of these indicators becomes greatly higher when myocardial ischemic injury becomes more serious. The concentration of these indicators goes down when CAD becomes relieve. All of the indicators have positive relationship with the clinical situation of CAD. Consequence,serum IL-8,TNF-α,IL-10 as indicators,have clinical values as diagnosis,clinical situation evaluation and treatment performance for CAD.更多还原