【摘要】 目的:观察复合右美托咪定与硝酸甘油在正颌手术中的降压效果。方法:选择颌面外科施行的上或下颌骨畸形矫正术患者40例,随机均分为观察组（D组）和对照组（N组）各20例。术中D组持续泵注右美托咪定,N组持续泵注硝酸甘油施行控制性降压处理,使血压维持在适当的水平,直至终止控制降压。所有患者均施行慢诱导经鼻气管插管,静吸复合全身麻醉维持。分别于插管成功后泵注右美托咪定、硝酸甘油前即刻（T₀）、降压至靶目标时（T₁）、截骨前即刻（T₂）、截骨后5 min（T₃）、停药时（T₄）、停药15 min（T₅）、停药30 min（T₆）记录ABP、MAP、HR的变化。结果:两组患者术中ABP、MAP、HR波动N组明显大于D组,差异有统计学意义（P<0.05）。结论:右美托咪定在正颌外科手术中可以维持血流动力稳定,协同镇痛药减少其用量。更多还原

【Abstract】 Objective To observe the effect of controlled hypotension by dexmedetomidine and nitroglycerin in orthognathic operation. Method Forty patients undergoing orthognathic operation were randomly divided into 2 groups: observation group( D group)( n =20),control group( N group)( n = 20). in the operation,In group D continuous Dexmedetomidine and in group N continue nitroglycerin was given intravenously,Keeping blood pressure at the appropriate level. All patients were slow induced nasal endotracheal intubation,intravenous anesthesia and inhalation anesthesia maintain general anesthesia. ABP、MAP、HR were recorded before anesthesia and during the phase of controlled hypotension. Results Two groups of patients with intraoperative ABP MAP HR fluctuations N were significantly greater than D group,the difference was statistically significant( P < 0. 05). Conclusion Dexmedetomidine in orthognathic operation can maintain hemodynamic stability and synergistic analgesic to reduce their dosage.更多还原