【摘要】 目的:探讨艾司西酞普兰联合认知行为疗法(CBT)对高三学生考前焦虑、抑郁的疗效。方法:选择在唐山市第五医院就诊的一定数量有过度考前焦虑、抑郁的高中学生,随机分为两组,研究组应用艾司西酞普兰联合CBT进行治疗,对照组单用艾司西酞普兰进行治疗,分别于治疗前、治疗4周、治疗8周和治疗12周后用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)以及药物副反应量表(TESS)进行评定,结果进行统计学分析。结果:治疗前HAMA评分两组间均无显著差异(t=-0.14,P>0.05);经治疗4周后,研究组HAMA评分均显著低于对照组(t=-2.23,P<0.05),并显著低于治疗前(t=2.23,P<0.05);治疗8周后两组HAMA评分无显著差异(t=-0.74,P>0.05),研究组显著低于治疗前(t=2.58,P<0.05);治疗12周后,研究组HAMA评分再次显著低于对照组(t=-2.26,P<0.05),与治疗前相比有极显著差异(t=5.98,P<0.01)。治疗前HAMD评分两组间均无显著差异(t=1.73,P>0.05);经治疗4周后,研究组HAMD评分均显著低于对照组(t=-2.16,P<0.05),并显著低于治疗前(t=2.10,P<0.05);治疗8周后两组HAMD评分无显著差异(t=0.22,P>0.05),研究组显著低于治疗前(t=2.38,P<0.05);治疗12周后,研究组HAMD评分与对照组无显著差异(t=-0.16,P>0.05),与治疗前相比有显著差异(t=2.03,P<0.05)。两组均未发生严重药物不良反应(χ2=0.32,P>0.05)。结论:艾司西酞普兰联合CBT治疗考前焦虑、抑郁起效快,疗效肯定,对于考前焦虑的远期疗效优于单用艾司西酞普兰;耐受性好,安全性高。更多还原

【Abstract】 Objective:To explore into the effect of escitalopram combined with cognitive behavioral therapy(CBT)on anxiety and depression before examinations among senior high students in Tangshan.Methods:A certain number of senior high students,who suffered from anxiety as well as depression before examinations received a therapy in Tangshan No.5hospital.They were divided randomly into two groups,ie.the control group and the experiment group.The experiment group was treated with escitalopram combined with cognitive behavioral therapy(CBT)while the control group was treated only with escitalopram.Their levels of anxiety and depression were evaluated respectively before the treatment,at the end of four weeks’ treatment,at the end of eight weeks’ treatment and at the end of twelve weeks of treatment with Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)and drug side effects scale(TESS).Then the results were statistically analyzed and compared.Results:Before the treatment,there was no significant difference between the HAMA scores of the two groups(t=-0.14,P>0.05);After four weeks of treatment,the HAMA scores of the experiment group were significantly lower than those of the control group(t=-2.23,P<0.05)and than the scores before treatment(t=2.23,P <0.05);after eight weeks of treatment,no clear difference was found between the HAMA scores of the two groups(t=-0.74,P>0.05)and the HAMA scores of the experiment group were significantly lower than that before the treatment(t=2.58,P<0.05);after twelve weeks of treatment,the HAMA scores of the experiment group were lower than those of the control group again,and the difference was significant(t=-2.26,P<0.05),and compared with the scores before the treatment,the difference had the largest significance(t=5.98,P<0.01).Before the treatment,no significant difference was found between the HAMD scores of both groups(t=1.73,P>0.05);after four weeks of treatment,the HAMD scores of the experiment group were significantly lower than that in the control group(t=-2.16,P<0.05)or before the treatment(t=2.10,P<0.05);after eight weeks of treatment,no significant difference was found between the HAMD scores of both groups(t=0.22,P>0.05),the HAMD scores of the experiment group were much lower than before the treatment(t=2.38,P<0.05);after twelve weeks of treatment,no significant difference was found between the HAMD scores of the two groups(t=-0.16,P>0.05),the HAMD scores of the experiment group were significant different from those before the treatment(t=2.03,P<0.05).Neither group had serious adverse drug reaction(χ2=0.32,P>0.05).Conclusion:Escitalopram combined with CBT treatment works fast on anxiety and depression before examinations and shows a positive effect,which is better than the effect of using escitalopram alone.And the combined therapy shows more tolerance and higher safety among the patients.更多还原