【摘要】 目的探讨中年男性健康体检人群的理想心血管健康行为和因素与血浆致动脉硬化指数(atherogenic index of plasma,AIP)的相关性。方法采用横断面研究,选择本院健康体检人群中的中年男性27 824例,采用问卷调查,人体测量和实验室检测总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹血糖,以美国心脏协会(AHA)理想心血管健康行为和因素的定义为标准,分析其与AIP的相关性。结果 AHA 7项指标处于理想状态的比例分别为总胆固醇68.5%,空腹血糖66.9%,体质量指数50.2%,身体活动45.6%,吸烟40.3%,血压22.5%,食盐摄入15.6%;7项指标与AIP均呈显著相关(P<0.05),相关性大小依次为体质量指数、总胆固醇、空腹血糖、吸烟、血压、身体活动和食盐摄入;AIP均数随着7项指标各自评分分值的减少而增加(P<0.05);心血管健康状况处于不良、中等和良好的人群,其动脉硬化高危风险的比例分别是61.0%、38.4%和21.3%(χ2=1178.878,P=0.000);在校正年龄的情况下,理想心血管健康评分每增加1分,AIP数值降低0.046,动脉硬化高危风险降低22.3%(OR=0.777,95%CI为0.768~0.787)。结论理想心血管健康行为和因素与AIP呈负相关,AIP可作为心血管疾病高危风险人群的监测指标。心血管健康评分≤6或AIP≥0.219的人群,是动脉硬化的高危人群。更多还原

【Abstract】 Objective To evaluate the relationship between ideal cardiovascular health behavior and factors and the atherogenic index of plasma(AIP) in middle-aged Chinese men. Methods A cross-sectional study was performed,and a total of27,824 middle-aged Chinese men were enrolled. Based on the definition of ideal cardiovascular health proposed by the American Heart Association,the association between ideal cardiovascular health behaviors and factors and AIP was analyzed. Results The percentages of the ideal health behavior and factors were as follows :total cholesterol(TC),68.5%;fasting blood glucose(FBG),66.9%;body mass index(BMI),50.2%;physical activity,45.6%;smoking,40.3%;blood pressure,22.5% and salt intake,15.6%. All the 7 indicators of ideal health are negatively related to AIP(P < 0.05),and rank ordering by degree of correlation are BMI,TC,FBG,smoking,blood pressure,physical activity,and salt intake. The high-risk of developing atherosclerosis are 61.0%,38.4% and 21.3%in subjects with inadequate,average and optimum cardiovascular health status. The results of Logistic regression showed that,after age adjusted,while a 1-point increase in the cardiovascular health score resulted a 0.046 reduction in AIP and a 22.3% reduction in the high-risk of developing atherosclerosis(OR = 0.777,95% CI:0.768–0.787). Conclusion The ideal cardiovascular health behavior and the factors are negatively correlated with AIP,and AIP can be used as a monitoring index of the risk of cardiovascular disease.The population which ideal cardiovascular health scores ≤ 6 or AIP ≥ 0.2186 may be the high-risk population of developing atherosclerosis.更多还原