【摘要】 电离辐射(IR)诱导的造血干细胞(HSCs)损伤是IR后引发机体死亡的主要原因,其损伤机制主要涉及P53-Puma通路诱导HSCs凋亡;激活G-CSF/Stat3/BATF依赖性的分化检验点促进HSCs分化;ROS-P38通路诱导HSCs衰老以及损伤HSCs龛。近期研究为预防和治疗电离辐射引起的骨髓抑制提供了理论基础。更多还原

【Abstract】 Hematopoietic stem cell( HSCs) injury induced by ionizing radiation( IR) is the primary cause of death after exposure to ionizing radiation. The mechanisms of inducing HSCs damage include induction of HSCs apoptosis via the P53-Puma pathway; promotion of HSCs differentiation via the activation of the G-CSF / Stat3 / BATF-dependent differentiation checkpoint; induction of HSCs senescence via the ROS-P38 pathway; and damage to the HSCs niche. Recent researches provide a basis for the prevention and treatment of bone marrow suppression caused by ionizing radiation.更多还原