【摘要】 目的 评价奥氮平联合氟哌啶醇治疗颅脑外伤后躁狂性精神障碍的效果和安全性。方法 选取新乡市第一人民医院2015年6月~2016年12月间采用奥氮平联合氟哌啶醇治疗的60例脑外伤后躁狂的患者为研究组;以同期采用奥氮平治疗的60例脑外伤后躁狂的患者为对照组;两组患者均连续治疗4周。分别于治疗前和治疗2周、4周后对两组患者进行B-R躁狂表(BRMS)评分和临床疗效总评分表(CGI-SI)评分,并根据4周后BRMS评分与治疗前评分的减分率评估治疗效果;观察两组患者治疗过程中不良反应的发生情况。结果 研究组的总治疗有效率、痊愈率均高于对照组,差异有统计学意义(P<0.05)。研究组与对照组患者治疗前BRMS评分、CGI-SI评分之间差异无统计学意义(P>0.05);随着治疗时间延迟长,研究组与对照组BRMS评分、CGI-SI评分均下降,与治疗前相比差异有统计学意义(P<0.05);治疗后研究组BRMS评分、CGI-SI评分均低于同期对照组,差异有统计学意义(P<0.05)。研究组与对照组治疗期间口干、震颤、视物模糊、头晕头痛等不良反应发生率之间差异均无统计学意义(P>0.05)。结论 奥氮平联合氟哌啶醇治疗颅脑外伤后躁狂性精神障碍的疗效满意且起效快,值得推广应用。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of olanzapine combined with haloperidol in the treatment of manic psychosis after traumatic brain injury. Methods Totals of 60 manic patients after traumatic brain injury treated with olanzapine combined haloperidol were selected from the First People’s Hospital of Xinxiang in June 2015 to December 2016. In the same period, 60 patients with mania after brain trauma treated with olanzapine were enrolled as control group. Patients in two groups were treated continuously for 4 weeks.All patients underwent B-R Mania Scale(BRMS) and clinical efficacy total score(CGI-SI) before and after treatment for 2 weeks and 4 weeks.The effect of treatment was assessed by the reduction rate of BRMS score and the CCI-SI score after 4 weeks. The adverse reactions in two groups were observed. Results The total effective rate and cure rate of the study group were significantly higher than that of the control group(P < 0.05). There was no significant difference in the BRMS score and CGI-SI score between two groups before treatment(P>0.05).The BRMS score and CGI-SI score of the study group and control group decreased significantly compared with prior tratment(P < 0.05). After treatment, the BRMS score and CGI-SI score of study group were significantly lower than that of control group(P < 0.05). There was no significant difference in the incidence of adverse reactions such as dry mouth, tremor, blurred vision, dizziness and headache between two groups(P> 0.05). Conclusions Olanzapine combined with haloperidol is effective and has quick onset in the treatment of manic psychosis after traumatic brain injury. It is worthy of popularization and application.更多还原