【摘要】 目的探讨晚期恶性肿瘤引起中央气道狭窄的治疗中置入碘-125粒子支架和普通金属裸支架的疗效。方法方便选取该院呼吸科对2013年1月—2017年6月间收治的18例恶性中央气道狭窄的患者,分别行金属裸支架和碘-125粒子支架置入术,观察比较6个月内管腔再狭窄的情况,并用Cox比例风险回归分析两组患者发生再狭窄的风险比。结果普通支架组10例、粒子支架组8例均成功置入支架,迅速解除气管狭窄引起的呼吸困难和喘息症状。粒子支架组术后6个月管腔再狭窄的发生率显著低于普通支架组(P=0.043),且发生再狭窄的风险是普通裸支架组患者的15%[(风险比HR:0.15(95%可信区间:0.03~0.69),P=0.015)]。结论碘-125粒子支架用于恶性肿瘤阻塞中央气道的治疗,能够控制肿瘤病灶的发展、降低气管再狭窄发生的风险。更多还原

【Abstract】 Objective To discuss the curative effect of Iodine-125 particle stent and Bare metal stent in treatment of Central airway stenosis. Methods 18 cases of patients with malignant central airway stenosis for bare metal stent and odine-125 particle stent from January 2013 to June 2017 were conveniently selected and the lumen restenosis was observed in half a year was observed, and the risk ratio of restenosis was analyzed by the Cox ratio risk. Results The stent was successfully placed in 10 cases in the general stent group and 8 cases in the particle stent group, thus can rapidly solving the symptoms of dyspnea and gasp caused by tracheostenosis, and the incidence rate of restenosis in half a year in the particle stent group was obviously lower than that in the common stent group(P=0.043), and the occurrence risk of restenosis was 15% of patients in the common stent group [(risk ratio HR: 0.15(95% credibility interval 0.03~0.69),P=0.015)].Conclusion Iodine-125 particle stent in treatment of Central airway stenosis can control the development of tumor lesions and reduce the occurrence risk of tracheal restenosis.更多还原