【摘要】 目的通过对乳腺癌患者癌组织中雌激素受体β表达情况的检测,探讨乳腺癌内分泌治疗的临床疗效与癌组织ERβ表达的相关因素。方法以2014年1月—2016年6月到期间于该院就诊的临床资料完整、绝经女性84例,经过病理学确诊为乳腺癌患者,术后口服他莫昔芬进行内分泌治疗。通过免疫组化发,对ERβ阳性表达情况进行检测。结果 84例患者中,ERβ阳性表达52例,表达率为61.90%。ERβ阳性表达患者,与患者年龄、肿瘤大小、TNM分期、是否进行放疗及化疗等因素无关,组间分析差异无统计学意义(P>0.05)。ERβ阳性表达患者,进行内分泌治疗者,3年生存率与5年生存率显著大于未接受内分泌治疗者,差异有统计学意义(P<0.05)。ERβ阴性表达者相较于ERβ阳性表达者,3年生存率、5年生存率均差异无统计学意义,且进行内分泌治疗与未进行内分泌治疗,3年生存率、5年生存率均差异无统计学意义(P>0.05)。有效随访结果显示,ERβ阴性患者,无瘤生存时间为(78.6±10.2)个月,ERβ阳性患者,中位无瘤生存时间为(60.9±12.5)个月。结论乳腺癌的发生过程与ERβ表达存在密切关联,乳腺癌内分泌治疗的临床疗效与癌组织中ERβ表达存在相关性。更多还原

【Abstract】 Objective To discuss the clinical curative effect of breast cancer endocrinotherapy and analysis of correlative factor with cancer tissue ERβ expression. Methods 84 cases of menopause women with breast cancer diagnosed in our hospital from January 2014 to June 2016 were selected and took the tamoxifen orally for endocrinotherapy, and the ERβ expression positive expression situation was tested by the immunohistochemical method. Results Of 84 cases, there were 52 cases with ERβ positive expression, and the expression rate was 61.90%, and the patients with ERβ positive expression was not related to the age, tumor size, TNM stage and whether to receive the radiotherapy and chemotherapy, and the differences between the two groups were statistically significant(P>0.05), and the 3-year survival rate and 5-year survival rate were obviously higher than patients without endocrinotherapy, and the differences were statistically significant,(P<0.05) and the differences in the 3-year survival rate and 5-year survival rate between the two groups were not statistically significant,(P>0.05), and the effective follow-up results showed that the tumor-free survival time of ERβ negative patients was(78.6±10.2)months, and the median tumor-free survival time of ERβ positive patients was(60.9±12.5) months. Conclusion The occurrence course of breast cancer is closely correlated with the ERβ expression, and the clinical curative effect of breast cancer endocrinotherapy has a correlation with the ERβ expression in cancer tissues.更多还原