【摘要】 目的探讨妊娠期糖尿病、子痫前期与代谢综合征(MS)表型的相关性。方法收集单胎妊娠健康孕妇(对照组)110例,子痫前期孕妇41例,妊娠期糖尿病(GDM)孕妇51例,GDM合并子痫前期孕妇39例,比较4组孕妇的血压、空腹血糖、空腹胰岛素、总胆固醇、甘油三脂和体重增长程度;孕期体重增长与甘油三脂、胆固醇的关系。结果子痫前期、GDM和合并组孕妇在不同孕期的甘油三酯、胆固醇、空腹血糖和空腹胰岛素均高于同期对照组;子痫前期、GDM和合并组孕妇在不同孕期及整个孕期体重增长值均高于对照组;妊娠不同时期的体重增长与同期甘油三酯、胆固醇分别呈正相关。结论 GDM和子痫前期孕妇体内均有不同程度的脂代谢紊乱及胰岛素抵抗,且与代谢综合征一样有共同的高危因素——肥胖;GDM、子痫前期孕妇与MS有高度相关性。更多还原

【Abstract】 Objective To study the relationship between GDM,preeclampsia and the phenotype of metabolic syndrome.Methods Totally 110 cases of singleton healthy pregnant women(control group),41 pregnant women with preeclampsia,51 GDM and 39 both GDM and preeclampsia cases were collected.The blood pressure,fasting blood glucose,fasting insulin,cholestenone glycerin triglyceride,and weight growth of four groups were compared.The correlation between triglyceride,cholestenone and weight gain during pregnancy was also compared.Results The triglyceride,cholestenone,fasting blood glucose,fasting insulin in preeclampsia,GDM and both GDM and preeclampsia groups were higher than that of the control group.The weight gains during the pregnancy in the other three groups were higher than that of control group.The weight gains in different periods of pregnancy were positively correlated with triglyceride,cholestenone in the same period.Conclusions There are varying degrees of disorder of lipid metabolism and insulin resistance in GDM and preeclampsia,and also with the same high-risk factor,that is,obesity,as metabolic syndrome,GDM,preeclampsia and MS show highly correlation coefficients.更多还原