【摘要】 以二氯甲烷为溶剂,氯乙酰氯和苯甲醇反应,合成了氯乙酸苄酯。通过红外光谱、紫外光谱和核磁共振氢谱对氯乙酸苄酯结构进行了表征。采用单因素优选法,对反应时间、反应物比例、碱的种类和反应温度等可能影响氯乙酸苄酯收率的因素进行了讨论。结果表明,最适宜的合成条件反应温度为室温,反应时间90 min,n(氯乙酰氯)∶n(苯甲醇)=1.2∶1。氯乙酸苄酯产率为79.4%,高效液相色谱证明氯乙酸苄酯质量分数为98%。更多还原

【Abstract】 The synthesis of benzyl chloroacetate was achieved by the reaction of chloroacetyl chloride and benzyl alcohol with CH2Cl2 as a solvent.The reaction conditions including reaction time,temperature,and ratio of reactant and base were optimized.The yield of product with high purity reached 79.4%,when the ratio of chloroacetyl chloride to benzyl alcohol was 1.2∶1,and the reaction was performed at room temperature for 1.5hwithout the use of extra base.更多还原