【摘要】 标题化合物是合成杀菌剂叶菌唑的关键中间体。以异丁酸甲酯为原料,经过碳链增长、分子内Friedel-Crafts酰化、Baylis-Hillman反应、催化氢化、琼斯氧化等反应,摒弃了传统高毒性甲基化步骤,成功合成了叶菌唑戊酮,以初始原料异丁酸甲酯计算,总收率为47.5%,中间体及产物用~1HNMR及ESI-MS进行了表征。更多还原

【Abstract】 Metconazole-pentone is a key intermediate for the synthesis of metconazole.Methyl isobutyratewas treated by carbon chain growth,intramolecular Friedel-Crafts acylation,Baylis-Hillman reaction,catalytic hydrogenation and Jones oxidation etc to synthesize metconazole-pentone without the traditional highly toxic methylation step.This method was successful and the total yield was 47.5%.Important intermediates and products were confirmed with ~1HNMR and ESI-MS.更多还原