【摘要】 目的:观察减毒抑癌汤治疗肝肾亏虚型卵巢癌化疗后的临床疗效与安全性。方法:将64例晚期卵巢癌肝肾亏虚证患者随机分为2组各32例,治疗组采取减毒抑癌汤配合新辅助化疗,对照组单予新辅助化疗。治疗结束后评价2组患者近期临床疗效(包括中医证候疗效、消化道不良反应以及骨髓抑制情况)。结果:中医证候疗效总有效率治疗组为81.25%,明显高于对照组的50.00%,差异有统计学意义(P<0.05);2组治疗期间骨髓抑制情况比较(白细胞、中性粒细胞、血红蛋白及血小板减少程度),治疗组均优于对照组,差异有统计学意义(P<0.05);治疗组恶心、呕吐、腹泻、ALT升高程度低于对照组(P<0.01),口腔炎程度与对照组比较,差异无统计学意义(P>0.05)。结论:减毒抑癌汤配合新辅助化疗法治疗肝肾亏虚型卵巢癌,不仅能减轻因化疗导致的骨髓抑制情况,且未升高消化道不良反应发生率,临床疗效肯定。更多还原

【Abstract】 Objective: To investigate the clinical effect and safety of Jiandu Yiai decoction in the treatment of ovarian cancer with deficiency of liver and kidney after chemotherapy. Methods: A total of 64 patients with advanced ovarian cancer with deficiency of liver and kidney were randomly divided into treatment group and control group,with 32 patients in each group. The patients in the treatment group were given Jiandu Yiai decoction combined with neoadjuvant chemotherapy,and those in the control group were given neoadjuvant chemotherapy alone. The two groups were evaluated in terms of short-term clinical outcome( including the outcome of traditional Chinese medicine( TCM) syndrome,adverse gastrointestinal reactions,and myelosuppression). Results: The treatment group had a significantly higher overall response rate for TCM syndrome than the control group( 81. 25% vs 50. 00%,P < 0. 05). The treatment group had significantly better results of myelosuppression( the degree of reductions in leukocytes,neutrophils,hemoglobin,and platelets) than the control group( P < 0. 05). Compared with the control group,the treatment group had significantly lower degrees of nausea,vomiting,diarrhea,and elevation in alanine aminotransferase( P < 0. 01),while there was no significant difference in the degree of stomatitis between the two groups( P > 0. 05). Conclusion: In the treatment of ovarian cancer with deficiency of liver and kidney,Jiandu Yiai decoction combined with neoadjuvant chemotherapy can alleviate myelosuppression caused by chemotherapy and does not increase the incidence rate of adverse gastrointestinal reactions,and therefore,it has a marked clinical effect in the treatment of this disease.更多还原