Objective: To investigate the feasibility and safety of perimembranous ventricular septal defects(Pm VSD) closure solely by femoral vein approach under transesophageal echocardiography(TEE) guidance. Methods: From January 1, 2014 to May 31, 2016, 26 patients with Pm VSD in Second Xiangya Hospital were selected, with age at 3.2–6.0(4.3±0.7) years old and body weight at 15.0–19.5(16.7±1.4) kg. The diameter of VSD was 3.5–4.8(4.1±0.3) mm. All patients were treated by percutaneous Pm VSD closure solely by femor...