【摘要】 为了考察姜黄浸膏散对CCl₄所致的小鼠急性肝损伤的保护作用,采用不同剂量姜黄浸膏散（50、100、200 mg/kg）口灌给药小鼠一周,随后腹腔注射0.12%CCl₄攻毒,观察小鼠血清中AST、ALT以及肝组织匀浆中SOD、CAT、GSH-Px和MDA的变化情况。结果显示,姜黄浸膏散能够显著降低CCl₄所致肝损伤小鼠血清ALT、AST值（P<0.01或P<0.05）,降低肝匀浆中MDA含量,增加SOD、CAT、GSH-Px活性,明显改善肝组织的病理变化。表明姜黄浸膏散对CCl₄所致的小鼠急性肝损伤具有显著的保护作用。更多还原

【Abstract】 To explore the protective effect of extract powder of turmeric on carbon tetrachloride（CCl₄）-induced acute hepatic injury, the mice were administrated with extract powder of turmeric with different doses（50, 100, 200 mg/kg） for 7 d. Then the mice were treated with 0.12% CCl₄ by intraperitoneal injection. The levels of ALT, AST in serum and activities of SOD, CAT, MDA, GSH-Px in liver tissue were detected and the liver lesions were examined. The results showed that the activities of ALT, AST and the level of MDA in extract powder of turmeric group were significantly decreased, and the activities of SOD, CAT, GSH-Px were significantly increased, and liver pathology were improved compared with the injured group（P <0.05 or P<0.01）. It indicated that the extract powder of turmeric had significant protective effect against CCl₄ induced acute hepatic injury in mice.更多还原