【摘要】 目的分析肇庆地区腹泻患儿A群轮状病毒感染情况并探讨其发病规律。方法采用单克隆抗体免疫胶体金技术对2 116例腹泻患者的新鲜粪便中的A群轮状病毒抗原进行检测,并对RV阳性标本进行粪便常规检查和隐血试验。结果2 116例腹泻患者中A群轮状病毒阳性的有446例,阳性率为21.08%,其中6个月~2岁、2岁~3岁和3岁~5岁这三个年龄段阳性率最高,分别为26.75%、22.91%和21.60%;男女患儿RV阳性率差异无统计学意义(P>0.05);1、2、3月份间RV阳性率分别为46.42%、42.06%、38.07%,明显高于其他月份。城镇患儿(12.26%)与农村患儿(13.13%)的RV阳性率差异无统计学意义(P>0.05)。446例RV阳性患者中,粪便常规检查和隐血试验阴性361例,占80.98%;隐血试验阳性61例,占13.17%;镜下白细胞和红细胞阳性各占2.68%和0.48%,少量白细胞(<5个/HP)18例,占3.90%。结论 A群轮状病毒相关性腹泻的发生具有明显的地区和季节差异,应根据其易感人群、流行时间作出准确的诊断及治疗。更多还原

【Abstract】 Objective To investigate the prevalence of Group-A rotavirus infection among children with diarrhea of Zhaoqing Area in Guangdong Province,and to explore its pathogenesis regularity.Methods Fresh excreta samples of 2 116 patients with diarrhea were collected and group-A rotavirus was detected by monoclonal antibody immune colloidal gold device.Results 446 cases(21.08%) were positive for group-A rotavirus in all the 2116 cases.The positive rates of group-A rotavirus among 6 months to 2 year,2 to 3 years,3 to 5 years old were 26.75%,22.91% and 21.60%,which were significantly intended to be the high incidence age.There was of no statistical significant difference among male and female infants(P > 0.05).The positive rates of group-A rotavirus among children during January,February and March were 46.42%,42.06% and 38.07%,which were significantly higher than the other months.There was no statistically significant difference of the rotavirus’ positive rate between the patients lived in town(12.26%) and the rural patients(13.13%)(P > 0.05).In 446 RV positive patients,there were 361 negative cases in faeces routine test and occult blood test,accounting for 80.98%; and 61 positive cases in occult blood test,accounting for 13.17%; the RBCs and the WBCs under microscope accounted for 2.68% and 0.48% respectively,and a few WBCs(< 5/HP) could be seen in18 cases,accounting for 3.90%.Conclusion Group-A rotavirus is one of the main pathogen of infant diarrhea.This disease has obvious regional and seasonal differences.Accurate diagnosis and treatment should be made according to the susceptible groups and popular time.更多还原