【摘要】 研究槲寄生中N-桂皮酰基丁二胺在大鼠体内的药代动力学特点.大鼠灌胃给予N-桂皮酰基丁二胺,采集不同时间点的大鼠血浆,用HPLC法检测大鼠血浆中N-桂皮酰基丁二胺的浓度,并用DAS2.0药动学软件进行数据处理,计算药动学参数.N-桂皮酰基丁二胺在大鼠体内的药动学特征符合一室模型,药动学参数分别为:半衰期速率常数T_1/2（k_a）=0.343 h,分布半衰期T_1/2=1.306 h,达峰时间T_max=0.750 h,最大血药浓度C_max=1.700μg/m L,表观分布容积V_1/F=21.047 L·kg^-1,口服消除率C_L=11.172 L·h^-1·kg^-1,药时曲线下面积AUC（0-t）=4.129 h·mg·L^-1.N-桂皮酰基丁二胺口服给药后,吸收和分布均较快,且分布广泛,在血浆中的清除也较快.更多还原

【Abstract】 To study the pharmacokinetic character of N-cinnamoyl putrescine in rats,after the rats were administered by N-cinnamoyl putrescine through ig,HPLC was used to determine the concentration of N-cinnamoyl putrescine in blood plasma at different times,pharmacokinetic software DAS2. 0 was used to process the data. N-cinnamoyl putrescine was shown to be one-room distribution model in rats. The main pharmacokinetic parameters of N-cinnamoyl putrescine are as follows: T_1/2（k_a） = 0. 343 h,T_1/2= 1. 306 h,T_max= 0. 750 h,C_max= 1. 700 μg·m L^-1,V_1/F= 21. 047 L·kg^-1,C_L= 11. 172 L·h^-1·kg^-1,AUC（0-t） = 4. 129 h·mg·L^-1. It indicated that the absorption and distribution of N-cinnamoyl putrescine was rapid and wide. The distribution was broad and clearance was very quick in the plasma.更多还原