【摘要】 正电子发射断层成像(Positron Emission Tomography,PET)作为最灵敏和具有定量测量能力的功能分子影像技术,越来越广泛地应用于生物医学研究,如疾病的动物模型、新药物的研发和新治疗方法的评估等。提高探测器的性能是改进PET仪器性能的关键,PET探测器通常由分割的闪烁晶体阵列和光探测器组成,文中使用位置灵敏光电倍增管和不同晶体表面特性的硅酸钇镥((Lu,Y)2Si O5,LYSO)晶体阵列,对新型的双端读出三维PET探测器和传统的单端读出二维PET探测器的性能进行了测量。实验结果表明,对于双端读出PET探测器,两种晶体阵列提供相近的晶体分辨图和能量分辨率,但非抛光晶体阵列提供好的深度分辨率,双端读出PET探测器需要使用表面不抛光的晶体阵列;对单端读出PET探测器,抛光晶体阵列提供好的晶体分布图和能量分辨率,单端读出PET探测器需要使用表面抛光的晶体阵列。更多还原

【Abstract】 Background: Positron emission tomography（PET） is the most sensitive and quantitative functional and molecular imaging technique. It was more and more popularly used in modern biomedical research such as animal model of human disease, new drug development and evaluation of new therapies. Purpose: Improving the detector property is the key to increase the performance of the PET scanners. PET detector normally consists of a segmented scintillator array and a photodetector. Methods: In this work the performance of PET detectors consisting of（Lu,Y）₂SiO₅（LYSO） arrays with polished and unpolished crystal surface was measured by using both dual-ended and single-ended readout with position sensitive photomultiplier tube. Results: The experimental results showed that both LYSO arrays provided similar flood histogram and energy resolution for dual-ended readout detector, but the unpolished LYSO array provided much better resolution of interaction depth and should be used for dual-ended readout PET detectors. Conclusion: Polished LYSO array provided better flood histogram and energy resolution, and should be used for single-ended readout PET detector.更多还原