In consideration of the screening method for priority control organic pollutants and monitoring data of Shijiazhuang's air quality,a principle for screening volatile organic compounds( VOCs) was developed. 20 compounds,including 7 halohydrocarbons,5 aromatic hydrocarbons,3 esters,2 ketones,1 alkene,1 aldehyde and 1 sulfide,were screened out from the VOCs with high detection and contribution rates,and high risks to health. The pharmaceutical industries who use these VOCs might be the major sources.