【摘要】 层层自组装(LBL)技术可以通过改变组装的构筑单元及组装层数调控多层膜表面的物理、化学性质.使用层层自组装技术对生物材料表面进行改性,构筑纳米粒子复合涂层引入药物,可改善材料表面的生物相容性和功能特性.采用十六烷基三甲基溴化铵(CTAB)为模板,通过正硅酸四乙酯(TEOS)的溶胶-凝胶法(Sol-gel)制得介孔硅(MSN);再将带负电MSN与带正电聚二烯丙基二甲基氯化铵(PDDA)交替组装,得到了介孔硅纳米涂层.研究了多层膜的层层自组装形成,并考察了涂层的载药性能;通过在介孔硅纳米涂层上表面引入PDDA-衍生层(覆盖层),增强了涂层中的药物的缓释特性.这种具有缓释功能的多层膜有望应用于医学临床.更多还原

【Abstract】 Layer-by-layer assembly( LBL) technology can control and endow the surface of multilayer films special physical and chemical properties by changing the building compounds and the numbers of layer.Using LBL technology,nanoparticles-embedded multilayer films with incorporated drugs can be deposited onto the surface of biomaterials,which enhances material biocompatibility and functionality. Mesoporous silica particles( MSN) were synthesized through sol-gel method of tetraethyl orthosilicate( TEOS) with hexadecyl trimethyl ammonium bromide( CTAB) as templet. MSN-embedded multilayer films were then built via alternative assembly of negatively-charged MSN and positively-charged poly( dimethyl-diallylammonium chloride)( PDDA). The LBL assembly formation of the MSN and PDDA were investigated and the drug loading capacities of the films were also determined. By introducing PDDA-derivative layers( cover layers) on the uppermost surface of MSN-embedded multilayer film, the drug sustained property was significantly improved. The developed multilayer films with sustained release property have great potential in clinic medical treatment.更多还原