【摘要】 目的:观察盐酸氢吗啡酮与舒芬太尼用于剖宫产术后静脉自控镇痛(PCIA)的效果及安全性。方法:选择120例单胎孕妇随机分为HM组(氢吗啡酮组,n=60):盐酸氢吗啡酮8mg+盐酸托烷司琼5mg加0.9%的氯化钠溶液稀释至100ml;SF组(舒芬太尼组,n=60):盐酸舒芬太尼100μg+盐酸托烷司琼5mg加0.9%的氯化钠溶液稀释至100ml。两组PCIA均设为2ml/h恒速输注,PCIA单次追加剂量为0.5ml,时间锁定为15min,镇痛时间约为48h。结果:氢吗啡酮组与舒芬太尼组相对比,两组的镇痛评分、镇静评分、按压次数均无统计学差异(P>0.05),并且不良反应发生率两组均较低。结论:氢吗啡酮用于剖宫产术后静脉自控镇痛效果确切,不良反应少,镇痛作用类似于舒芬太尼。更多还原

【Abstract】 Objective:To observe the effect and security of hydromorphone hydrochloride and sufentanil on patient-controlled intravenous analgesia(PCIA)after cesarean sections.Methods:One hundred and twenty pregnant women with singleton for operation were randomized into two groups:Group HM(hydromorphone hydrochloride,n=60)was injected with total volume of 100 ml analgesic drug contained 8g hydromorphone hydrochloride and 5mg tropisetron mixed with normal saline.Group SF(sufentanil,n=60)was infused total 100 ml volume of 100μg sufentanil hydrochloride and 5mg tropisetron mixed with normal saline.Both groups were set up 2ml/h constant-speed infusion.Single additional dose of PCIA is 0.5ml within 15 min,and the total analgesia time lasted for 48 h.Results:There were no statistical differences in VAS,sedation scale and pressure times between above two groups(P>0.05);At the same time,the occurrences of adverse reaction are both very low in these two groups.Conclusion:The analgesic effect of hydromorphone hydrochloride,like sufentanil,may be definite when used in PCIA after cesarean sections with less adverse reactions.更多还原