【摘要】 目的探讨依达拉奉联合阿托伐他汀钙对老年血管性痴呆患者血液流变学及颈动脉硬化斑块的影响。方法选择2012年2月—2015年6月收治的老年血管性痴呆105例,根据治疗方法分为观察组55例和对照组50例,对照组采取依达拉奉治疗,观察组采用依达拉奉联合阿托伐他汀钙治疗。观察2组治疗前后简易智能状态量表(MMSE)、日常生活能力量表(ADL)、血脂水平、血液流变学、颈动脉硬化斑块大小变化情况。结果治疗后,2组MMSE、一氧化氮(NO)水平较治疗前均明显上升,ADL评分、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、全血高低切黏度、血浆黏度、纤维蛋白原、颈动脉内膜中层厚度(IMT)及颈动脉粥样硬化斑块大小较治疗前下降(P<0.05)。观察组治疗后MMSE和血清血管内皮生长因子(VEGF)、NO水平高于对照组,ADL评分、TC、TG、LDL-C、全血高低切黏度、血浆黏度、纤维蛋白原、IMT、颈动脉粥样硬化斑块大小低于对照组(P<0.05)。2组均无严重不良反应。结论依达拉奉联合阿托伐他汀钙治疗老年血管性痴呆,具有较好的调脂作用,还能改善患者血液流变学指标及血管内皮细胞功能,促进颈动脉硬化斑块缩小,有利于患者认知障碍及日常生活能力改善。更多还原

【Abstract】 Objective To investigate effects of Edaravone combined with Atorvastatin Calcium Tablets on hemorheology and carotid atherosclerotic plaques in elderly patients with vascular dementia. Methods A total of 105 elderly patients with vascular dementia admitted between February 2012 and June 2015 were divided into observation group( n =55) and control group( n = 50) according to treatment methods. Control group was treated with Edaravone,while observation group was treated with Edaravone combined with Atorvastatin Calcium Tablets. Mini-Mental State Examination( MMSE) scale,activity of daily living( ADL) scale,blood fat levels,hemorheology and changes of carotid atherosclerotic plaques were observed before and after treatment in two groups. Results After treatment,in two groups,MMSE and nitric oxide( NO) levels were significantly increased compared with those before treatment,while ADL Score,total cholesterol( TC),triglyceride( TG),low density lipoprotein cholesterol( LDL-C),high and low shear whole blood viscosity,plasma viscosity,fibrinogen,carotid intima-media thickness( IMT) levels and size of carotid atherosclerotic plaques were significantly decreased compared with those before treatment( P < 0. 05). After treatment,in observation group,MMSE score,serum vascular endothelial growth factor( VEGF) and NO levels were significantly higher,while ADL score,TC,TG,LDL-C,high and low shear whole blood viscosity,plasma viscosity,fibrinogen and IMT levels,and size of carotid atherosclerotic plaques were significantly lower than those in control group( P < 0. 05). There were no severe adverse events in both groups. Conclusion Edaravone combined with Atorvastatin Calcium Tablets in treatment of elderly patients with vascular dementia can well regulate lipid,improve hemodynamic indexes and vascular endothelial cell function and promote carotid atherosclerotic plaques narrowing,and it is conductive to the improvement of cognitive disorder and activities of daily living ability of patients.更多还原