【摘要】 细胞色素P450酶是药物体内代谢的关键酶,药物合用时可能因与同一种代谢酶的相互作用,导致药物在体内的处置过程发生改变。本文旨在探讨常见的细胞色素P450酶相关药物相互作用类型和其机制,为临床联合用药的合理、安全、有效提供依据。更多还原

【Abstract】 Cytochrome P450 s are the key enzymes during drug metabolism.Combination of drugs might lead to changes of pharmacokinetics due to interactions on the same enzyme.This article aims to explore common types and mechanism of cytochrome P450s-related drug interactions,which provides the basis of reasonable,safe and effective drug combinations in clinics.更多还原